Asymmetric Synthesis of 2-Acetyl-4(5)-(1,2,4-trihydroxybutyl)imidazoles
A method for preparing trihydroxybutyl analogues of the biologically active compound 2-acetyl-4(5)-(1,2,3,4-tetrahydroxybutyl)imidazole (THI) is reported.This method employs a palladium(0)-catalyzed coupling of 1-(ethoxymethyl)-4-iodoimidazole (3a) to fun
Cliff, Matthew D.,Pyne, Stephen G.
p. 2378 - 2383
(2007/10/02)
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