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71759-89-2

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  • 4-Iodoimidazole CAS 71759-89-2 1H-Imidazole,5-iodo- CAS no 71759-89-2 5-Iodo-1H-imidazole

    Cas No: 71759-89-2

  • USD $ 3.5-5.0 / Kiloliter

  • 5 Kiloliter

  • 3000 Metric Ton/Month

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71759-89-2 Usage

Chemical Properties

White Solid

Uses

suzuki reaction

Check Digit Verification of cas no

The CAS Registry Mumber 71759-89-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,1,7,5 and 9 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 71759-89:
(7*7)+(6*1)+(5*7)+(4*5)+(3*9)+(2*8)+(1*9)=162
162 % 10 = 2
So 71759-89-2 is a valid CAS Registry Number.
InChI:InChI=1/C3H3IN2/c4-3-1-5-2-6-3/h1-2H,(H,5,6)

71759-89-2 Well-known Company Product Price

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  • Alfa Aesar

  • (L20184)  4(5)-Iodoimidazole, 94%   

  • 71759-89-2

  • 250mg

  • 462.0CNY

  • Detail
  • Alfa Aesar

  • (L20184)  4(5)-Iodoimidazole, 94%   

  • 71759-89-2

  • 1g

  • 1574.0CNY

  • Detail
  • Alfa Aesar

  • (L20184)  4(5)-Iodoimidazole, 94%   

  • 71759-89-2

  • 5g

  • 6204.0CNY

  • Detail
  • Aldrich

  • (L510513)  4-Iodoimidazole  AldrichCPR

  • 71759-89-2

  • L510513-1G

  • 321.75CNY

  • Detail

71759-89-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Iodoimidazole

1.2 Other means of identification

Product number -
Other names 1H-IMIDAZOLE,4-IODO

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:71759-89-2 SDS

71759-89-2Relevant articles and documents

Preparation method of 4-iodo-1H-imidazole

-

Paragraph 0021-0026, (2020/04/17)

The invention provides a preparation method of 4-iodo-1H-imidazole. The preparation method comprises the following steps: (1) enabling imidazole, iodine and a cosolvent for promoting the solubility ofiodine in water to react under an alkaline condition in the presence of water as a solvent, after the reaction is finished, adjusting the pH value to 7-9, filtering out precipitated white solids, performing extraction, reduced pressure distillation to remove the solvent, and recrystallization on the filtrate to recover imidazole, concentrating the recrystallized mother liquor, and mixing the obtained white solids and the precipitated white solids to obtain a 4-iodo-1H-imidazole crude product, and (2) recrystallizing the 4-iodo-1H-imidazole crude product twice to obtain a white crystal 4-iodo-1H-imidazole pure product. The method has the advantages of simple process, high reaction yield, low production cost and recyclable raw materials.

Discovery of imidazoleisoindole derivatives as potent IDO1 inhibitors: Design, synthesis, biological evaluation and computational studies

Zou, Yi,Wang, Fang,Wang, Yan,Sun, Qirui,Hu, Yue,Li, Yuezhen,Liu, Wen,Guo, Wenjie,Huang, Zhangjian,Zhang, Yihua,Xu, Qiang,Lai, Yisheng

, p. 293 - 304 (2017/10/05)

Indoleamine-2,3-dioxygenase-1 (IDO1) is an attractive target for cancer immunotherapy. Herein, a series of novel imidazoleisoindole derivatives were prepared and evaluated for their ability to inhibit IDO1. Among these, derivative 11r was the most active compound with nanomolar potency in the Hela cell-based assay, while showed negligible cellular toxicity. UV-visible spectra study demonstrated that compounds 11p and 11r bound to IDO1 and coordinated with the heme iron. Furthermore, they could significantly promote T cell proliferation, increase IFN-γ production, and reduce the numbers of Foxp3+ regulatory T cells. Finally, induced fit docking (IFD) and quantum mechanics/molecular mechanics (QM/MM) calculation were performed to understand the interactions of these compounds to IDO1 protein, which provided a comprehensive guide for further structural modification and optimization.

Imidazo isoindole IDO1 inhibitor as well as preparation method and application thereof

-

Paragraph 0085; 0086; 0089; 0090, (2018/01/11)

The invention belongs to the field of medicine, and particularly relates to an imidazo isoindole IDO1 compound with structural characteristics of the formula (I) shown in the description as well as a three-dimensional isomer or a pharmaceutically acceptable salt thereof, a preparation method thereof and application thereof as an indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor. An experiment result shows that the compound of the invention has a significant inhibition effect for the activity of IDO1, can effectively promote the proliferation of cells T, prevents initial cells T from being differentiated into adjustable cells T, can invert IDO1 mediating immunosuppression, can be used for treating relevant diseases with pathological features of an IDO1 mediating kynurenine metabolic way including cancers, virus infection, neurodegenerative diseases, cataracts, organ transplant rejection, depression, autoimmune diseases and the like.

Preparation method of 4-halogen-1H-imidazole

-

Paragraph 0031; 0034, (2017/08/28)

The invention discloses a preparation method of 4-halogen-1H-imidazol. The method comprises the following steps: (1), enabling imidazole and halogen elementary substance which are taken as raw materials to be in reaction at a temperature of 60 to 100 DEG C in an alkaline condition, and filtering after the reaction, so as to obtain a filter cake 4-halogen-1H-imidazol crude product; (2), enabling the 4-halogen-1H-imidazol crude product and a reducing agent to be in reaction, filling and filtering after the reaction, and performing extraction and vacuum concentration on the filter cake, so as to obtain a 4-halogen-1H-imidazol pure product. The method is simple in technology, high in reaction yield, low in cost, and free from pollution and waste liquid discharge.

Scope and Mechanistic Limitations of a Sonogashira Coupling Reaction on an Imidazole Backbone

Sandtorv, Alexander H.,Bj?rsvik, Hans-René

, p. 4658 - 4666 (2015/08/03)

A Sonogashira coupling reaction method to join terminal alkynes to the imidazole backbone was developed and investigated. The method exhibits good functional group tolerance and provides target 4-alkynylated imidazoles in 70-93% yield. The alkyne reagents were characterized by means of DFT calculations, from which electrostatic potential surfaces (EPS) were produced. A clear correlation between the EPS of the triple bond and the success of the coupling reaction was revealed. If the EPS is in range -94 to -105 kJmol-1 the coupling is successful. An unsuccessful class of reagents (alkynols) was made compatible by means of an auxiliary group (tert-butyldimethylsilyl). EPSs of these modified reagents then resembled those of the model and these auxiliary-assisted reagents then coupled successfully in excellent yields.

Fast halogenation of some N-heterocycles by means of N,N'-dihalo-5,5- dimethylhydantoin

Sandtorv, Alexander H.,Bjorsvik, Hans-Rene

, p. 499 - 507 (2013/05/08)

An instantaneous, selective and high-yielding halogenation process is reported. The method operates with imidazoles, pyrazoles, and indoles under benign reaction conditions. The developed process involves the use of N,N'-dihalo-5,5-dimethylhydantoins (halo=chlorine, bromine, iodine) as halogenation reagents that are activated by catalytic quantities of a strong Bronsted acid. Moreover, the halogenation process is switchable to produce either the mono- or di-halogenated products. Issues related to the reaction mechanism are investigated and a proposal for a reaction mechanism is disclosed.

BENZOXAZEPIN COMPOUNDS SELECTIVE FOR PI3K P110 DELTA AND METHODS OF USE

-

Page/Page column 118, (2012/10/08)

Benzoxazepin Formula I compounds, including stereoisomers, geometric isomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting the delta isoform of PI3K, and for treating disorders mediated by lipid kinases such as inflammation, immunological disorders, and cancer. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Synthesis and biological evaluation of a novel anti-malarial lead

Hammond, Nicholas L.,Choi, Seoung-Ryoung,Carvalho, Paulo,Liu, Hua,Khan, Shabana,Avery, Mitchell A.

experimental part, p. 401 - 407 (2012/05/04)

Malaria is re-emerging in many tropical areas of the world and is often fatal due to drug resistance, leading to about a million deaths each year. Multiple drug resistance has required new efforts in drug discovery and development. Thus, the search for new drugs operating by novel mechanisms of action is receiving increased attention. Herein we report the synthesis and biological evaluation of a novel anti-malarial with micromolar activity against resistant strains of the parasite.

Regioselective iodination of arenes using iodine/NaBO3· 4H2O system in ionic liquid

Bhilare, Sachin V.,Deorukhkar, Amol R.,Darvatkar, Nitin B.,Salunkhe, Manikrao M.

, p. 2881 - 2888 (2008/12/22)

A mild, efficient, and simple protocol was developed for iodination of arenes and heterocyclic compounds with molecular iodine catalyzed by sodium perborate in ionic liquid. The methodology offered iodoarenes in good to excellent yields at room temperature. The protocol proved to be highly selective, as a single isomer was formed exclusively in most of the substrates. Copyright Taylor & Francis Group, LLC.

4-Benzyl-1H-imidazoles with oxazoline termini as histamine H3 receptor agonists

Wijtmans, Maikel,Celanire, Sylvain,Snip, Erwin,Gillard, Michel R.,Gelens, Edith,Collart, Philippe P.,Venhuis, Bastiaan J.,Christophe, Bernard,Hulscher, Saskia,Van Der Goot, Henk,Lebon, Florence,Timmerman, Henk,Bakker, Remko A.,Lallemand, Bénédicte I. L. F.,Leurs, Rob,Talaga, Patrice E.,De Esch, Iwan J. P.

supporting information; experimental part, p. 2944 - 2953 (2009/04/11)

Research on the therapeutic applications of the histamine H3 receptor (H3R) has traditionally focused on antagonists/inverse agonists. In contrast, H3R agonists have received less attention despite their potential use in s

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