163914-13-4

Basic information

• Product Name: 5-bromo-4-(bromomethyl)-2-methoxypyridine
• Synonyms: 5-bromo-4-(bromomethyl)-2-methoxypyridine
• CAS NO: 163914-13-4
• Molecular Formula: C₇H₇Br₂NO
• Molecular Weight: 280.94458
• Mol File: 163914-13-4.mol

Chemical Properties

• Boiling Point: 295.8±35.0 °C(Predicted)
• Appearance: /
• Density: 1.844±0.06 g/cm3(Predicted)
• PKA: 0.62±0.18(Predicted)
• CAS DataBase Reference: 5-bromo-4-(bromomethyl)-2-methoxypyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-4-(bromomethyl)-2-methoxypyridine(163914-13-4)
• EPA Substance Registry System: 5-bromo-4-(bromomethyl)-2-methoxypyridine(163914-13-4)

Safety Data

• Hazardous Substances Data: 163914-13-4(Hazardous Substances Data)

Upstream product

• 164513-39-7 5-bromo-2-methoxy-4-methylpyridine 
• 164513-38-6 2-hydroxy-5-bromo-4-methylpyridine 
• 98198-48-2 2-amino-5-bromo-4-methylpyridine 

Relevant articles and documents

(Hetero)-aryl ketones derivatives with antibacterial properties

Conformationally restricted aryl and heteroaryl ketones derived from monic acid have useful antibacterial properties.

Preparation of E-(2-substituted-1-methylethylidene)indanones derived from monic acid

Alkylation of the lithium dienolate of the monic acid hydroxamate (3) with o-bromo(bromomethyl) benzene or heteroaromatic derivatives gave α-alkylated products (5). This alkylation procedure was surprisingly catalysed by 4- dimethylaminopyridine. Metal-halogen exchange with t-butyl lithium occurred with concomitant intramolecular cyclisation to give a mixture of the deconjugated ketones (6). Reconjugation with potassium t-butoxide stereoselectively produced the E-isomer (7). Deprotection gave the monic acid derived ketone (1).