164033-12-9

Basic information

• Product Name: (S)-(-)-1-PHENYLPROPYL ISOCYANATE
• Synonyms: (S)-(-)-1-PHENYLPROPYL ISOCYANATE
• CAS NO: 164033-12-9
• Molecular Formula: C₁₀H₁₁NO
• Molecular Weight: 161.2
• Mol File: 164033-12-9.mol

Chemical Properties

• Boiling Point: 195-196°C 7mm
• Flash Point: 195-196°C/7mm
• Appearance: /
• Density: 0.97±0.1 g/cm3(Predicted)
• Refractive Index: 1.5145
• Sensitive: Moisture Sensitive
• BRN: 6799586
• CAS DataBase Reference: (S)-(-)-1-PHENYLPROPYL ISOCYANATE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(-)-1-PHENYLPROPYL ISOCYANATE(164033-12-9)
• EPA Substance Registry System: (S)-(-)-1-PHENYLPROPYL ISOCYANATE(164033-12-9)

Safety Data

• Hazard Codes: Xn
• Statements: 20/22-36/37/38-42-52-22
• Safety Statements: 23-26-36/37/39-45
• RIDADR: 2206
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 164033-12-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(S)-(-)-1-PHENYLPROPYL ISOCYANATE is used as a building block for the synthesis of various organic compounds, particularly in the pharmaceutical industry. Its ability to react with a wide range of nucleophiles makes it a valuable component in the development of new drugs and medicinal compounds.
Used in Agrochemical Industry:
In the agrochemical industry, (S)-(-)-1-PHENYLPROPYL ISOCYANATE is utilized as a key component in the creation of various agrochemicals. Its reactivity allows for the synthesis of compounds that can be used in the development of pesticides, herbicides, and other agricultural products.
Safety Precautions:
It is important to handle (S)-(-)-1-PHENYLPROPYL ISOCYANATE with caution, as it is known to be an irritant to the skin, eyes, and respiratory system. Repeated exposure may cause sensitization, so proper safety measures and handling procedures should be followed when working with this compound to minimize potential health risks.

Upstream product

• 75-44-5 phosgene 
• 3789-59-1 (R)-1-phenylpropylamine 
• 32315-10-9 bis(trichloromethyl) carbonate 

Downstream Products

• 1161825-74-6 (S)-3-(1-phenylpropyl)-8-carbamoylimidazo[5,1-d][1,2,3,5]tetrazin-4-one 
• 1110641-90-1 (R)-6-allyl-3-((S)-1-(4-bromophenyl)propyl)-6-phenyl-1,3-oxazinan-2-one 

Relevant articles and documents

SYNTHESIS OF INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1

Disclosed are syntheses of 11 beta-HSD1 inhibitors and corresponding intermediates that are promising for the treatment of a variety of disease states including diabetes, metabolic syndrome, obesity, glucose intolerance, insulin resistance, hyperglycemia, hypertension, hypertension-related cardiovascular disorders, hyperlipidemia, deleterious gluco-corticold effects on neuronal function (e.g. cognitive impairment, dementia, and/or depression), elevated intra-ocular pressure, various forms of bone disease (e.g., osteoporosis), tuberculosis, leprosy (Hansen's disease), psoriasis, and impaired wound healing (e.g., in patients that exhibit impaired glucose tolerance and/or type 2 diabetes).

Orally Active β-Lactam Inhibitors of Human Leukocyte Elastase. 3. Stereospecific Synthesis ans Structure-Activity Relationships for 3,3-Dialkylazetidin-2-ones

The stereospecific synthesis of several 4--3,3-dialkyl-1-carbonyl>azetidin-2-ones 3 is described in which the C-3 alkyl groups were varied from methyl to butyl as well as allyl, benzyl and methoxymethyl.The str