Synthesis of novel 6-α and 6-β-alkylcarbonylmethyl substituted penems
6-α and 6-β Alkylcarbonylmethyl penems were synthesized from 6-α-bromo and 6-oxo penicillanates respectively and their in vitro antibacterial activity was studied. The compounds were generally active against Gram-positive but not against Gram-negative strains, the compounds of the 6-β series being more active. Relatively to imipenem, taken as reference compound, the penems resulted more stable towards chemical hydrolysis in Tris-HCl buffered medium (pH 7.4) but more sensitive towards dehydropeptidase-I (DHP-I).
Get Best Price for164034-08-63-Methyl-2-[(3S,4R)-3-(2-methyl-allyl)-2-oxo-4-phenylacetylsulfanyl-azetidin-1-yl]-but-2-enoic acid 2,2-dimethyl-propionyloxymethyl ester