Journal of Antibiotics p. 399 - 407 (1995)
Update date:2022-08-04
Topics:
Pentassuglia
Tarzia
Andreotti
Bismara
Carlesso
Donati
Gaviraghi
Perboni
Pezzoli
Rossi
Tamburini
Ursini
6-α and 6-β Alkylcarbonylmethyl penems were synthesized from 6-α-bromo and 6-oxo penicillanates respectively and their in vitro antibacterial activity was studied. The compounds were generally active against Gram-positive but not against Gram-negative strains, the compounds of the 6-β series being more active. Relatively to imipenem, taken as reference compound, the penems resulted more stable towards chemical hydrolysis in Tris-HCl buffered medium (pH 7.4) but more sensitive towards dehydropeptidase-I (DHP-I).
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(2015)Doi:10.1021/acs.joc.0c02582
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