164352-89-0

Basic information

• Product Name: 2-(prop-2-en-1-ylsulfanyl)pyrazine
• Synonyms: 2-(allylthio)pyrazine; pyrazine, 2-(2-propen-1-ylthio)-
• CAS NO: 164352-89-0
• Molecular Formula: C₇H₈N₂S
• Molecular Weight: 152.2168
• Mol File: 164352-89-0.mol

Chemical Properties

• Boiling Point: 238.2°C at 760 mmHg
• Flash Point: 97.8°C
• Density: 1.13g/cm³
• Vapor Pressure: 0.0664mmHg at 25°C
• Refractive Index: 1.568
• CAS DataBase Reference: 2-(prop-2-en-1-ylsulfanyl)pyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(prop-2-en-1-ylsulfanyl)pyrazine(164352-89-0)
• EPA Substance Registry System: 2-(prop-2-en-1-ylsulfanyl)pyrazine(164352-89-0)

Safety Data

• Hazardous Substances Data: 164352-89-0(Hazardous Substances Data)

Upstream product

• 106-95-6 allyl bromide 
• 38521-06-1 2-mercaptopyrazine 
• 14508-49-7 2-chloropyrazin 
• 870-23-5 prop-2-ene-1-thiol 

Relevant articles and documents

Heterocyclic Allylsulfones as Latent Heteroaryl Nucleophiles in Palladium-Catalyzed Cross-Coupling Reactions

Heterocyclic sulfinates are effective reagents in palladium-catalyzed coupling reactions with aryl and heteroaryl halides, often providing high yields of the targeted biaryl. However, the preparation and purification of complex heterocylic sulfinates can be problematic. In addition, sulfinate functionality is not tolerant of the majority of synthetic transformations, making these reagents unsuitable for multistep elaboration. Herein, we show that heterocyclic allylsulfones can function as latent sulfinate reagents and, when treated with a Pd(0) catalyst and an aryl halide, undergo deallylation, followed by efficient desulfinylative cross-coupling. A broad range of allyl heteroarylsulfones are conveniently prepared, using several complementary routes, and are shown to be effective coupling partners with a variety of aryl and heteroaryl halides. We demonstrate that the allylsulfone functional group can tolerate a range of standard synthetic transformations, including orthogonal C- and N-coupling reactions, allowing multistep elaboration. The allylsulfones are successfully coupled with a variety of medicinally relevant substrates, demonstrating their applicability in demanding cross-coupling transformations. In addition, pharmaceutical agents crizotinib and etoricoxib were prepared using allyl heteroaryl sulfone coupling partners, further demonstrating the utility of these new reagents.

Chemopreventive compounds and a preparation method and use thereof

Disclosed herein is a compound having formula (I), wherein R 1 represents a hydrogen atom or a C 1-3 alkyl group; and R 2 represents phenyl and furanyl group, or a group represented by the formula: --C(R a) C(R b)(R c), wherein R a, R b, and R c, being the same or different from each other, means hydrogen atom or methyl or phenyl group. The present invention further provides a method for preparing the compound (I) and a composition comprising as an active ingredient the compound (I). The compound (I) of the present invention can effectively inhibit the expression of enzymes involved in phase I reaction while activating the expression of enzymes involved in phase II reaction, thereby can be advantageously used to protect liver from being injured by various chemicals.