- Synthesis and Insecticidal Activity of Novel Thiazole Acrylonitrile Derivatives
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A series of novel thiazole acrylonitrile derivatives was designed and synthesized utilizing NC-510 as a precursor. Their structures were characterized by NMR spectrometry, MS, and elemental analysis. The results of bioassay indicated that some of these ti
- Cao, Shengwen,Liu, Aiping,Liu, Weidong,Liu, Xingping,Ren, Yeguo,Pei, Hui,Huang, Lu,Zheng, Xi,Huang, Mingzhi,Wu, Daoxin
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p. 3395 - 3402
(2017/11/21)
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- Acrylonitrile type compound and use thereof
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The invention discloses an acrylonitrile type compound as shown in a formula (I) as well as a preparation method and application of the acrylonitrile type compound, (as shown in the description), wherein Ar1, Ar2, R, R1, R2, X, Y and n have definitions as
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Paragraph 0120; 0122
(2017/02/02)
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- Pyrazolyl thiazolyl acrylonitrile compounds and use thereof
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The present invention discloses a novel structure pyrazolyl thiazolyl acrylonitrile compound or a stereoisomer thereof, wherein the structure of the compound is represented by a general formula I, R1 is selected from C1-C6 alkyl, halogenated C1-C6 alkyl,
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Paragraph 0078; 0079; 0080
(2017/01/17)
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- Thiazolyl acrylonitrile compound and use thereof
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The invention discloses a thiazolyl acrylonitrile compound with novel structure or stereoisomers thereof. The compound has a general formula as shown in a general formula I. R is selected from C1-C6 alkyl, halogenated C1-C6 alkyl, C3-C8 cycloalkyl and C1-
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Paragraph 0069-0071
(2016/10/08)
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- Phenyl thiazolyl acrylonitrile compound and use thereof
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The invention discloses a phenyl thiazolyl acrylonitrile compound with novel structure or stereoisomers thereof. The compound has a structure as shown in a formula I. R1 is selected from C1-C6 alkyl, halogenated C1-C6 alkyl, C3-C8 cycloalkyl, C1-C6 alkylo
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Paragraph 0095-0097
(2016/10/08)
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- 2- [...] azoly acrylonitrile compound and use thereof
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The invention discloses a 2-chloro thiazolyl acrylonitrile compound or a stereisomer thereof with a novel structure. The structure of the compound is shown as the general formula I in the specification, wherein R is one of alkyl of C1-C6, halogenated alkyl of C1-C6, cycloalkyl of C3-C8 and alkoxy of C1-C6; Q is selected from the group shown as the specification; R1 is one of H, halogen, methyl and trifluoromethyl; R2 is one of H and halogen. The compound in the general formula I has excellent insect and mite killing activity, and can be used for preventing and controlling insects and mites.
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Paragraph 0104-0106
(2016/10/08)
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- Acrylonitrile compound, and preparation method and application thereof
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The invention discloses an acrylonitrile compound shown as the formula (I), and a preparation method and application thereof. Ar , Ar, R, W and Y in the formula (I) have definitions given in the description. The compound in the formula (I) has insec
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Paragraph 0109; 0112
(2017/10/24)
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- Hit-to-Lead Optimization of a Novel Class of Potent, Broad-Spectrum Trypanosomacides
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The parasitic trypanosomes Trypanosoma brucei and T. cruzi are responsible for significant human suffering in the form of human African trypanosomiasis (HAT) and Chagas disease. Drugs currently available to treat these neglected diseases leave much to be
- Russell, Stephanie,Rahmani, Rapha?l,Jones, Amy J.,Newson, Harriet L.,Neilde, Kevin,Cotillo, Ignacio,Rahmani Khajouei, Marzieh,Ferrins, Lori,Qureishi, Sana,Nguyen, Nghi,Martinez-Martinez, Maria S.,Weaver, Donald F.,Kaiser, Marcel,Riley, Jennifer,Thomas, John,De Rycker, Manu,Read, Kevin D.,Flematti, Gavin R.,Ryan, Eileen,Tanghe, Scott,Rodriguez, Ana,Charman, Susan A.,Kessler, Albane,Avery, Vicky M.,Baell, Jonathan B.,Piggott, Matthew J.
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p. 9686 - 9720
(2016/11/19)
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- HETEROCYCLIC COMPOUNDS AND USE OF SAME
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Novel heterocyclic compounds are provided which display useful efficacy in the treatment of diseases caused by trypanosomatids. Particularly, the compounds of the invention are useful in the treatment of HAT and/or Chagas disease and/or Animal African trypanosomiasis (AAT).
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Paragraph 0025; 00209
(2016/01/08)
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- Etylene derivatives and pesticides containing said derivatives
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Ethylene derivatives of formula (I): where Q is an unsubstituted or substituted phenyl or heterocyclic group, especially a 4-thiazolyl, 1- or 3-pyrazolyl, 1,3-oxazol-4-yl, phenyl or pyridyl group; E is a substituent such as a cyano group; A is a substituent such as a 4-pyrazolyl or thiazolyl group; and B is a substituent such as an alkylcarbonyl group. Agricultural chemicals and agents for preventing the attachment of aquatic organisms containing one or more such ethylene derivatives.
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