Synthesis and Antimicrobial Screening of 2-Aryl-5-((2-arylthiazol-4-yl)methyl)-1,3,4-oxadiazole Derivatives
A new series of 2-aryl-5-((2-arylthiazol-4-yl)methyl)-1,3,4-oxadiazole derivatives was synthesized by condensation of 2-(2-substituted thiazol-4-yl)acetohydrazide with aryl aldehydes followed by oxidative cyclocondensation using iodobenzene diacetate. The
Mhaske, Pravin C.,Shelke, Shivaji H.,Bhoye, Manish,Bobade, Vivek D.
Hit-to-Lead Optimization of a Novel Class of Potent, Broad-Spectrum Trypanosomacides
The parasitic trypanosomes Trypanosoma brucei and T. cruzi are responsible for significant human suffering in the form of human African trypanosomiasis (HAT) and Chagas disease. Drugs currently available to treat these neglected diseases leave much to be
Russell, Stephanie,Rahmani, Rapha?l,Jones, Amy J.,Newson, Harriet L.,Neilde, Kevin,Cotillo, Ignacio,Rahmani Khajouei, Marzieh,Ferrins, Lori,Qureishi, Sana,Nguyen, Nghi,Martinez-Martinez, Maria S.,Weaver, Donald F.,Kaiser, Marcel,Riley, Jennifer,Thomas, John,De Rycker, Manu,Read, Kevin D.,Flematti, Gavin R.,Ryan, Eileen,Tanghe, Scott,Rodriguez, Ana,Charman, Susan A.,Kessler, Albane,Avery, Vicky M.,Baell, Jonathan B.,Piggott, Matthew J.
p. 9686 - 9720
(2016/11/19)
Synthesis and Antifungal Screening of 2-(2-Aryl-4-methyl-thiazol-5-yl)-5-((2-aryl/benzylthiazol-4-yl)methyl)-1,3,4-oxadiazole Derivatives
(Chemical Equation Presented) A new series of synthesis and biological screening of 2-(2-aryl-4-methyl-thiazol-5-yl)-5-((2-aryl/benzylthiazol-4-yl)methyl)-1,3,4-oxadiazole derivatives 5a-i was achieved by condensation of 2-(2-aryl/benzylthiazol-4-yl)aceto
Novel heterocyclic compounds are provided which display useful efficacy in the treatment of diseases caused by trypanosomatids. Particularly, the compounds of the invention are useful in the treatment of HAT and/or Chagas disease and/or Animal African trypanosomiasis (AAT).
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Paragraph 00143; 00144
(2016/01/08)
Development of new thiazole-based iridium catalysts and their applications in the asymmetric hydrogenation of trisubstituted olefins
New thiazole-based chiral N,P-ligands that are open-chain analogues of known cyclic thiazole ligands have been synthesized and evaluated in the iridium-catalyzed asymmetric hydrogenation of trisubstituted olefins. Chirality was introduced into the ligands through a highly diastereoselective alkylation using Oppolzer's camphorsultam as chiral auxiliary. In general, the new catalysts are as reactive and selective as their cyclic counterparts for the asymmetric hydrogenation of various trisubstituted olefins. This journal is The Royal Society of Chemistry.
Cheruku, Pradeep,Paptchikhine, Alexander,Ali, Muhammad,Neudoerfl, Joerg-M.,Andersson, Pher G.
p. 366 - 373
(2008/10/09)
IMIDAZO(1,2-a)PYRIDINE DERIVATIVE
A compound reprsented by the following formula (I), its salts or nsolvates thereof capable of specifically or selectively expressig an antifungal activity in a broad spectrum based on the novel mechanism thereof of 1,6-β-glucan synthesis inhibition, and an antifungal agent containing any of them.
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Page 87
(2010/02/09)
1,2-disubstituted-6-oxo-3-phenyl-piperidine-3-carboxamides and combinatorial libraries thereof
The invention relates to combinatorial libraries containing two or more novel piperidine-3-carboxamide derivative compounds, methods of preparing the piperidine-3-carboxamide derivative compounds and piperidine-3-carboxamide derivative compounds bound to a resin
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(2008/06/13)
4H-pyrano[4,3-d]thiazole derivatives and process therefor
4H-Pyrano[4,3-d]thiazole derivatives characterized by having a 4H-pyrano[4,3-d]thiazole nucleus having a phenyl substituent at position 2 and a substituent at position 4, said substituent incorporating an acidic or basic function therein, are disclosed. T
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(2008/06/13)
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