164670-73-9

Basic information

• Product Name: 5-BROMO-2,3-DIMETHOXY-BENZONITRILE
• Synonyms: BUTTPARK 153\33-75;5-BROMO-2,3-DIMETHOXY-BENZONITRILE
• CAS NO: 164670-73-9
• Molecular Formula: C₉H₈BrNO₂
• Molecular Weight: 242.07
• Mol File: 164670-73-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-BROMO-2,3-DIMETHOXY-BENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2,3-DIMETHOXY-BENZONITRILE(164670-73-9)
• EPA Substance Registry System: 5-BROMO-2,3-DIMETHOXY-BENZONITRILE(164670-73-9)

Safety Data

• Hazardous Substances Data: 164670-73-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-BROMO-2,3-DIMETHOXY-BENZONITRILE is used as a key building block for the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical industry, 5-BROMO-2,3-DIMETHOXY-BENZONITRILE serves as a crucial component in the production of agrochemicals, aiding in the creation of effective solutions for agricultural applications.
Used as a Reagent in Chemical Research:
5-BROMO-2,3-DIMETHOXY-BENZONITRILE is utilized as a reagent in chemical research, facilitating scientific investigations and the advancement of knowledge in the field of chemistry.
Environmental Considerations:
5-BROMO-2,3-DIMETHOXY-BENZONITRILE is considered a potential environmental contaminant. Therefore, its use and handling must be conducted with appropriate safety measures to mitigate any adverse effects on the environment.

Upstream product

• 71295-21-1 5-bromo-2,3-dimethoxybenzaldehyde 
• 148-53-8 3-methoxy-2-hydroxybenzaldehyde 
• 5034-74-2 5-bromo-3-methoxysalicylaldehyde 
• 107188-91-0 5-bromo-2,3-dimethoxybenzoic acid chloride 
• 72517-15-8 2,3-dihydroxy-5-bromobenzoic acid 
• 72517-23-8 5-bromo-2,3-dimethoxybenzoic acid 
• 303-38-8 2,3-Dihydroxybenzoic acid 
• 407610-17-7 N-tert-butyl-5-bromo-2,3-dimethoxybenzamide 
• 108-24-7 acetic anhydride 

Downstream Products

• 407610-18-8 2-(2,3-dimethoxy-5-bromophenyl)-4-(hydroxymethyl)imidazole 
• 1027904-03-5 2-(5-Bromo-2,3-dimethoxy-phenyl)-5-chloromethyl-1H-imidazole 
• 407610-20-2 2-(2,3-dimethoxy-5-bromophenyl)imidazole-4-carboxaldehyde 
• 1333472-48-2 5-(furan-2-yl)-2,3-dimethoxybenzonitrile 
• 1057585-79-1 2,3-dimethoxy-5-bromobenzamide oxime 
• 1026468-85-8 5-Bromo-2,3-dimethoxy-benzamidine 

Relevant articles and documents

Synthesis of 3-(5-bromo-2,3-dimethoxy-phenyl)-[1, 2, 4] oxadiazole analogues and their evaluation as anti-Parkinson's agents

A series of 3-(5-bromo-2,3-dimethoxy-phenyl)-[1, 2, 4] oxadiazole derivatives was prepared and their evaluation for anti-Parkinson's activity was measured in vivo using albino rats. The result of the biological activity studies indicated that some of the

Synthesis of 2-(2,3-dimethoxyphenyl)-4-(aminomethyl)imidazole analogues and their binding affinities for dopamine D2 and D3 receptors

A series of 2-(2,3-dimethoxyphenyl)-4-(aminomethyl)imidazole derivatives was prepared and their affinity for dopamine D2 and D3 receptors was measured using in vitro binding assays. Several oxadiazole analogues were also prepared and tested for their affinity for dopamine D2 and D3 receptors. The results of receptor binding studies indicated that the incorporation of an imidazole moiety between the phenyl ring and the basic nitrogen did not significantly increase the selectivity for dopamine D3 receptors, whereas the incorporation of an oxadiazole at the same region resulted in a total loss of affinity for both dopamine receptor subtype binding sites. The most selective compound in this series is 2-(5-bromo-2,3-dimethoxyphenyl)-4-(6,7-dimethoxy-1,2,3, 4-tetrahydroisoquinolinomethyl)imidazole (5i), which has a D3 receptor affinity of 21 nM and a 7-fold selectivity for D3 versus D2 receptors. The binding affinity for σ1 and σ2 receptors was also measured, and the results showed that several analogues were selective σ1 receptor ligands.

2-Phenyl-4-(aminomethyl)imidazoles as Potential Antipsychotic Agents. Synthesis and Dopamine D2 Receptor Binding

A series of 2-phenyl-4-(aminomethyl)imidazoles were designed as conformationally restricted analogs of the dopamine D2 selective benzamide antipsychotics.The title compounds were synthesized and tested for blockade of YM-09151 binding in cloned African green monkey dopamine D2 receptor preparations.The binding affinity data thus obtained were compared against that of the benzamides and a previously described series of 2-phenyl-5-(aminomethyl)pyrroles.