5034-74-2Relevant articles and documents
Stereocontrolled Formal Synthesis of Platencin
Hsu, Day-Shin,Hwang, Tai-Yu
, p. 4689 - 4695 (2018)
A stereocontrolled formal synthesis of platencin was accomplished in 11 steps from a bromophenol derivative, with an overall yield of 13 %. The intermolecular Diels–Alder reaction of masked o-benzoquinone and an aldol condensation were the key steps in th
Substituent Effects and Mechanism in a Mechanochemical Reaction
Barbee, Meredith H.,Kouznetsova, Tatiana,Barrett, Scott L.,Gossweiler, Gregory R.,Lin, Yangju,Rastogi, Shiva K.,Brittain, William J.,Craig, Stephen L.
, p. 12746 - 12750 (2018)
We report the effect of substituents on the force-induced reactivity of a spiropyran mechanophore. Using single molecule force spectroscopy, force-rate behavior was determined for a series of spiropyran derivatives substituted with H, Br, or NO2/sub
A synthetic preparation method for small carbags hydrochloric acid
-
, (2021/12/08)
The present invention belongs to the field of organic chemistry, relates to a method of synthesizing berberine hydrochloride, comprising: S1: with 5-halo-o-quinoastearaldehyde and piperine ethylamine to obtain N- [2-(3,4-dimethoxyphenyl-5-yl) ethyl] -1- (5-halo-2,3-dimethoxybenzyl) methylimide; S2: to obtain 2- (3,4-diimoxyphenyl) -N- (5-bromo-2,3-dimethoxybenzyl) ethylamine; S3: to obtain 2-(3,4-dimethoxyphenyl) -N- (5-bromo-2 S4: to obtain 12-halogenated berberine derivative; S5: to obtain berberine. The present invention is free from the application of the by-product o-vanillin synthesis of o-resveratal raw material constraints, synthesis of 5- substitute o-resveratal and piperine ethylamine, and the use of the two preparation of berberine hydrochloride, with raw materials readily available, mild reaction conditions, easy to operate, high chemical yield, low cost and other advantages.
Synthetic method 5 - bromo -1 and 2,3 - trimethoxy benzene
-
Paragraph 0038-0040; 0045-0054, (2021/10/30)
The synthesis method of 5 -bromo -1-2,3 -methoxy benzene comprises the following steps: S1, taking the vanillin as a starting raw material, and brominating 5 - bromo -2 - hydroxyl -3 -methoxybenzaldehyde through the hydroxyl group para-position. S2 is obt