Cytostatic tetrazole-butenolide conjugates: Linking tetrazole and butenolide rings via stille coupling and biological activity of the target substances
A series of tetrazoles linked to the butenolide core via benzene rings were prepared by the Stille coupling reaction of α-(tributylstannyl) butenolides and 5-(alkylsulfanyl)-1-(4-iodophenyl)tetrazoles, and the compounds were tested for antifungal and cytostatic activity. Interesting antifungal activities against the filamentous strain Absidia corymbifera, and cytostatic activities against leukemic cells HL-60 and CCRF-CEM were found. The cytostatic activity requires the presence of both the butenolide ring and the alkylsulfanyl group bound to tetrazole ring. In addition, the feasibility of Pd-coupling reactions with 5-iodotetrazoles was evaluated.
Balsanek, Vojtech,Tichotova, Lucie,Kunes, Jiri,Spulak, Marcel,Pour, Milan,Votruba, Ivan,Buchta, Vladimir
scheme or table
p. 1161 - 1178
(2010/04/28)
5-IODOTETRAZOLES
The invention relates to compounds of formula (I) wherein R1 represents hydrogen or respectively optionally substituted alkyl, alkenyl, alkinyl or phenyl, said compounds being highly suitable as microbicides for protecting plants and materials.
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Page/Page column 20
(2008/06/13)
5-Halo-1-phenyltetrazoles
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Collibee,Nakajima,Anselme
p. 468 - 469
(2007/10/02)
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