16517-53-6

Basic information

• Product Name: 1-(3-hydroxypropyl)urea
• CAS NO: 16517-53-6
• Molecular Formula: C₄H₁₀N₂O₂
• Molecular Weight: 118.1344
• Mol File: 16517-53-6.mol

Chemical Properties

• Boiling Point: 268.7°C at 760 mmHg
• Flash Point: 116.3°C
• Density: 1.161g/cm³
• Vapor Pressure: 0.00102mmHg at 25°C
• Refractive Index: 1.487
• CAS DataBase Reference: 1-(3-hydroxypropyl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-hydroxypropyl)urea(16517-53-6)
• EPA Substance Registry System: 1-(3-hydroxypropyl)urea(16517-53-6)

Safety Data

• Hazardous Substances Data: 16517-53-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-(3-hydroxypropyl)urea is used as an active ingredient for its moisturizing and soothing properties, particularly in dermatological products. It helps alleviate skin irritation and dryness, providing a comfortable experience for users.
Used in Cosmetics Industry:
In the cosmetics industry, 1-(3-hydroxypropyl)urea is used as a key component in skincare products for its ability to enhance skin hydration and provide a soothing effect on the skin, contributing to the overall effectiveness of the product.
Used in Agriculture:
1-(3-hydroxypropyl)urea is utilized as a stabilizer in agricultural formulations, ensuring the consistent performance and effectiveness of the products used in this sector.
Used in Metalworking Fluids:
As a corrosion inhibitor, 1-(3-hydroxypropyl)urea is employed in metalworking fluids to prevent the degradation of metals and extend the life of machinery and tools, thereby improving the efficiency and longevity of industrial processes.

Upstream product

• 104096-61-9 N-benzyl-N'-(3-hydroxy-propyl)-urea 
• 590-28-3 potassium cyanate 
• 156-87-6 propan-1-ol-3-amine 

Downstream Products

• 461-72-3 2,4-imidazolidinedione 
• 1242015-38-8 2-(3-hydroxypropyl)-2,4,6,8-tetraazabicyclo[3.3.0]octane-3,7-dione 
• 1346780-24-2 1-(3-hydroxypropyl)-4,6-dimethyl-3a,6a-diphenyl-5-thioxooctahydroimidazo[4,5-d]imidazol-2-one 

Relevant articles and documents

Synthesis and Structure of 1-Substituted Semithioglycolurils

Two methods for the synthesis of previously unavailable 1-substituted semithioglycolurils were developed. These methods consist of the cyclocondensation of 1-substituted ureas with 4,5-dihydroxy- or 4,5-dimethoxyimidazolidine-2-thione or glyoxal, followed by the reaction of the resulting 1-substituted 4,5-dihydroxyimidazolidine-2-ones with HSCN in a two-step one-pot procedure. Two of the desired semithioglycolurils were obtained as conglomerates.

PROCESS FOR STRAIGHTENING KERATIN FIBRES WITH A HEATING MEANS AND DENATURING AGENTS

The invention relates to a process for straightening keratin fibres, comprising: (i) a step in which a straightening composition containing at least two denaturing agents is applied to the keratin fibres, (ii) a step in which the temperature of the keratin fibres is raised, using a heating means, to a temperature of between 110 and 250° C.

A simple conversion of amines into monosubstituted ureas in organic and aqueous solvents

A versatile and highly efficient synthesis of monosubstituted ureas is described. The reaction of an amine with 4-nitrophenyl-N-benzylcarbamate, followed by hydrogenolysis, provides the corresponding urea in high yield and purity. This carbamate can also be employed for the derivatization of water-soluble polyamines (e.g. aminoglycoside antibiotics), while other reagents (e.g. benzylisocyanate) fail to give the desired products in any significant yield.