165657-74-9Relevant articles and documents
METHODS FOR SYNTHESIS OF RESOLVINS
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Paragraph 0084, (2019/04/10)
The present invention provides methods for chemical synthesis of a resolvin compound such as resolvin E1 (RvE1), or a pharmaceutically acceptable salt thereof; and chemically stable formulations of said compound.
METHODS FOR TOTAL SYNTHESIS OF RESOLVIN E1
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, (2018/09/08)
The present invention provides methods for total chemical synthesis of Resolvin E1 (Rv E1).
Cobalt versus Osmium: Control of Both trans and cis Selectivity in Construction of the EFG Rings of Pectenotoxin 4
Roushanbakhti, Ahria,Liu, Yifan,Winship, Paul C. M.,Tucker, Michael J.,Akhtar, Wasim M.,Walter, Daryl S.,Wrigley, Gail,Donohoe, Timothy J.
supporting information, p. 14883 - 14887 (2017/10/24)
Catalytic oxidative cyclisation reactions have been employed for the synthesis of the E and F rings of the complex natural product target pectenotoxin 4. The choice of metal catalyst (cobalt- or osmium-based) allowed for the formation of THF rings with either trans or cis stereoselectivity. Fragment union using a modified Julia reaction then enabled the synthesis of an advanced synthetic intermediate containing the EF and G rings of the target.
AMINO GROUP-CONTAINING PYRROLIDINONE DERIVATIVE
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Paragraph 0186, (2014/01/08)
[Problems to be Solved by the Invention] To provide a drug having excellent antibacterial activity against Gram-positive bacteria and Gram-negative bacteria and also being excellent in terms of safety. [Means for Solving the Problems] A compound represented by the following formula (I) or a salt thereof: wherein R represents a hydrogen atom, a hydroxy group, or a halogen atom m represents an integer 0, 1, or 2, n represents an integer 0 or 1 Ar1 represents a bicyclic heterocyclic group represented by the following formula: wherein Aa represents a nitrogen atom or C-Ra, Ab represents a nitrogen atom or C-Rb, and Ac represents a nitrogen atom or C-Rc, Ra, Rb, and Rc independently represent a hydrogen atom or an alkyl group containing 1 to 6 carbon atoms, R1 and R2 independently represent a hydrogen atom, an alkoxy group containing 1 to 6 carbon atoms, a halogenoalkoxy group containing 1 to 6 carbon atoms, a halogen atom, or a cyano group, Ar2 represents a bicyclic heterocyclic group represented by the following formulae:
The first total synthesis of cytopiloyne, an anti-diabetic, polyacetylenic glucoside
Kumar, Chidambaram Ramesh,Tsai, Chi-Hui,Chao, Yu-Sheng,Lee, Jinq-Chyi
experimental part, p. 8696 - 8703 (2011/10/04)
The first total synthesis of cytopiloyne 1, a novel bioactive polyacetylenic glucoside isolated from the extract of Bidens pilosa, is described. The structure of cytopiloyne was determined to be 2-β-D-glucopyranosyloxy-1-hydroxytrideca-5,7,9,11-tetrayne by using various spectroscopic methods, but the chirality of the polyyne moiety was unknown. Herein, the convergent synthesis of two diastereomers of cytopiloyne by starting from commercially available 4-(2-hydroxyethyl)-2,2-dimethyl-1,3-diozolane is described. The synthetic sequence involved two key steps: stereoselective glycosylation of the glucosyl trichloroacetimidate with 1-[(4-methoxybenzyl)oxy] hex-5-yn-2-ol to give the desired β-glycoside and the construction of the glucosyl tetrayne skeleton by using a palladium/silver-catalyzed cross-coupling reaction to form the alkyne-alkyne bond, the first such use of this reaction. Comparison between the observed and published characterization data showed the 2R isomer to be the natural product cytopiloyne.
Stereoselective Additions of Chiral, Functionalized Organozinc Reagents to Achiral and Chiral Aldehydes: a Matched-Mismatched Case in Organozinc Chemistry
Koert, Ulrich,Wagner, Holger,Pidun, Ulrich
, p. 1447 - 1458 (2007/10/02)
The additions of the enantiomerically pure organozinc reagents 17 and 33 to the THF-aldehyde 1 in the presence of the monodentate Lewis acid boron trifluoride-ether give the nonchelation-controlled addition products 7 and 36, respectively (stereoselectivity 95:5, 86:14).These results provide a route to oligo(tetrahydrofuran)s with the relative stereochemistry trans-syn-cis.A stereodirecting effect of the chiral center in the organozinc reagent 17 is found, leading to simple diastereoselectivies in the reaction with achiral aldehydes and to a matched-mismatched case in the reaction with the chiral aldehyde 1. - Key Words: Addition, stereoselective, nonchelation-controlled / Reagent, organozinc / Stereodifferentiation, double / Oligo(tetrahydrofuran)