165657-75-0

Upstream product

• 5754-34-7 2-((4R)-2,2-dimethyl-1,3-dioxolan-4-yl)ethanol 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 165876-49-3 (2R,5R,2'S,5'S)-5-<5'-<(tert-butyldiphenylsiloxy)methyl>tetrahydro-2'-furyl>-1,2-O-isopropylidenepentane-1,2,5-triol 
• 149099-16-1 (2R,5S,2'S,5'S)-5-<5'-<(tert-Butyldiphenylsiloxy)methyl>tetrahydrofuran-2'-yl>-1,2-O-isopropylidenepentane-1,2,5-triol 
• 149099-18-3 (2R,5S,2'S,5'S,2''S,5''S)-1,2-O-Isopropylidene-5-<5'-<5''-<(tert-butyldiphenylsiloxy)methyl>tetrahydrofuran-2''-yl>tetrahydrofuran-2'-yl>pentane-1,2,5-triol 
• 165657-74-9 (2R)-4-iodo-1,2-O-isopropylidenebutane-1,2-diol 

Relevant academic research and scientific papers

METHODS FOR TOTAL SYNTHESIS OF RESOLVIN E1

The present invention provides methods for total chemical synthesis of Resolvin E1 (Rv E1).

Novel Carboxylic Acid and Antidepressant Composition Containing the Same as Active Ingredient

The present invention provides a novel compound and antidepressant composition that can be effectively used for improving depressed mood and depressed state, particularly for depressed mood and depressed state in menopausal women. The compound of the present invention is represented by the following formula (1): wherein R1 and R2 are identical or different and represent a hydrogen atom, a hydroxyl group or an acetyloxy group, and n is an integer of 2 to 7, or a pharmaceutically acceptable salt or ester thereof. This compound is used as an active ingredient in the antidepressant composition. Examples of the compound of the invention include (2E)-9,10-dihydroxy-2-decenoic acid, (2Z)-9,10-dihydroxy-2-decenoic acid, (2E)-9-hydroxy-2-decenoic acid, and (2E)-7-acetoxy-2-heptenoic acid.

CATIONIC LIPIDS AND USES THEREOF

Cationic lipids, cationic lipid based drug delivery systems, ways to make them and methods of treating diseases using them are disclosed.

Structural determination of montanacin D by total synthesis

(Chemical Equation Presented) The first total syntheses of acetogenin 3 and its 4S,8R-isomer are described. The key step involves intermolecular metathesis of an α,β-unsaturated ketone carrying a tetrahydropyranyl lactone with a tetrahydrofuran derivative

Stereoselective Synthesis of Oligo(tetrahydrofurans): Linear and Convergent Routes to Bi- and Tetrahydrofurans

The "dimeric" and "trimeric" oligo(tetrahydrofurans) (oligo-THFs) 24, 28, 32, and 38 were synthesized stereoselectively according to a linear and a convergent synthetic strategy.The oligo-THFs thus obtained are important intermediates for the synthesis of artificial ion channels.Furthermore, they can be used in the total synthesis of Annonaceae acetogenins, a class of natural occurring oligo-THFs with promising pharmacological properties. - Keywords: Synthesis, stereoselective / Oligo(tetrahydrofurans), natural, non-natural /Ion channels, artificial / Annonaceae acetogenins

Stereoselective Additions of Chiral, Functionalized Organozinc Reagents to Achiral and Chiral Aldehydes: a Matched-Mismatched Case in Organozinc Chemistry

The additions of the enantiomerically pure organozinc reagents 17 and 33 to the THF-aldehyde 1 in the presence of the monodentate Lewis acid boron trifluoride-ether give the nonchelation-controlled addition products 7 and 36, respectively (stereoselectivity 95:5, 86:14).These results provide a route to oligo(tetrahydrofuran)s with the relative stereochemistry trans-syn-cis.A stereodirecting effect of the chiral center in the organozinc reagent 17 is found, leading to simple diastereoselectivies in the reaction with achiral aldehydes and to a matched-mismatched case in the reaction with the chiral aldehyde 1. - Key Words: Addition, stereoselective, nonchelation-controlled / Reagent, organozinc / Stereodifferentiation, double / Oligo(tetrahydrofuran)