166182-90-7

Basic information

• Product Name: 5-AMINO-1-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID METHYL ESTER
• Synonyms: 5-AMINO-1-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID METHYL ESTER;1H-Pyrrole-2-carboxylicacid,5-amino-1-methyl-,methylester(9CI);Methyl 5-aMino-1-Methyl-1H-pyrrole-2-carboxylate;1H-Pyrrole-2-carboxylic acid, 5-aMino-1-Methyl-, Methyl ester
• CAS NO: 166182-90-7
• Molecular Formula: C7H10N2O2
• Molecular Weight: 154.17
• Product Categories: CARBOXYLICESTER;GLYCINESCAFFOLD
• Mol File: 166182-90-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-AMINO-1-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-1-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID METHYL ESTER(166182-90-7)
• EPA Substance Registry System: 5-AMINO-1-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID METHYL ESTER(166182-90-7)

Safety Data

• Hazardous Substances Data: 166182-90-7(Hazardous Substances Data)

Upstream product

• 37619-24-2 methyl N-methylpyrrole-2-carboxylate 
• 13138-75-5 N-methyl-5-nitropyrrole-2-carboxylic acid methyl ester 

Relevant articles and documents

Indirect C-H azidation of heterocycles via copper-catalyzed regioselective fragmentation of unsymmetrical λ3-iodanes

A C-H bond of electron-rich heterocycles is transformed into a C-N bond in a reaction sequence comprising the formation of heteroaryl(phenyl)iodonium azides and their in situ regioselective fragmentation to heteroaryl azides. A Cu(I) catalyst ensures complete regiocontrol in the fragmentation step and catalyzes the subsequent 1,3-dipolar cycloaddition of the formed azido heterocycles with acetylenes. The heteroaryl azides can also be conveniently reduced to heteroarylamines by aqueous ammonium sulfide. The overall C-H to C-N transformation is a mild and operationally simple one-pot sequential multistep process.

Synthesis of distamycin a polyamides targeting G-quadruplex DNA

A number of amide-linked oligopyrroles based on distamycin molecules have been synthesized by solid-state methods, and their interactions with a human intramolecular G-quadruplex have been measured by a melting procedure. Several of these molecules show an enhanced ratio of quadruplex vs. duplex DNA binding compared to distamycin itself, including one with a 2,5-disubstituted pyrrole group. Quadruplex affinity increases with the number of pyrrole groups, and it is suggested that this is consistent with a mixed groove/G-quartet stacking binding mode. The Royal Society of Chemistry 2006.

Polyaromatic amide compounds and pharmaceutical/cosmetic compositions comprised thereof

Novel pharmaceutically/cosmetically-active polyaromatic amides have the structural formula (I): STR1 wherein Z is a radical --CO--NH-- or --NH--CO--, and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.