37619-24-2

Basic information

• Product Name: METHYL 1-METHYLPYRROLE-2-CARBOXYLATE
• Synonyms: RARECHEM AL BF 0084;1-METHYLPYRROLE-2-CARBOXYLIC ACID METHYL ESTER;METHYL 1-METHYL-1H-PYRROLE-2-CARBOXYLATE;METHYL 1-METHYLPYRROLE-2-CARBOXYLATE;Methyl-4-methylpyrrole-2-carboxylate;1-Methyl-1H-pyrrole-2-carboxylic acid methyl ester;methyl N-methylpyrrole-2-carboxylate;1H-Pyrrole-2-carboxylicacid, 1-methyl-, methyl ester
• CAS NO: 37619-24-2
• Molecular Formula: C₇H₉NO₂
• Molecular Weight: 139.15
• EINECS: -0
• Mol File: 37619-24-2.mol
• Article Data: 15

Chemical Properties

• Melting Point: 80 °C (sublm)(Press: 0.2 Torr)
• Boiling Point: 96-98°C 15mm
• Flash Point: 96-98°C/15mm
• Appearance: /
• Density: 1.07 g/cm³
• Vapor Pressure: 0.26mmHg at 25°C
• Refractive Index: 1.5220
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -7.04±0.70(Predicted)
• Water Solubility: Slightly soluble in water.
• BRN: 116477
• CAS DataBase Reference: METHYL 1-METHYLPYRROLE-2-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 1-METHYLPYRROLE-2-CARBOXYLATE(37619-24-2)
• EPA Substance Registry System: METHYL 1-METHYLPYRROLE-2-CARBOXYLATE(37619-24-2)

Safety Data

• Safety Statements: S24/25:Avoid contact with skin and eyes.
• HazardClass: IRRITANT
• Hazardous Substances Data: 37619-24-2(Hazardous Substances Data)

Usage

Uses

Methyl 1-methylpyrrole-2-carboxylate is used as chemical and organic Intermediates.

InChI:InChI=1/C7H9NO2/c1-8-5-3-4-6(8)7(9)10-2/h3-5H,1-2H3

Upstream product

• 186581-53-3 diazomethane 
• 6973-60-0 1-Methyl-2-pyrrolecarboxylic acid 
• 1193-62-0 methyl Pyrrole-2-carboxylate 
• 74-88-4 methyl iodide 
• 96-54-8 N-Methylpyrrole 
• 7087-68-5 N-ethyl-N,N-diisopropylamine 
• 67-56-1 methanol 
• 56-23-5 tetrachloromethane 
• 1192-58-1 N-methylpyrrole aldehyde 
• 13515-93-0 N-methylglycine methyl ester hydrochloride 
• 1611-78-5 1,3-bis-dimethylaminotrimethinium perchlorate 
• 616-38-6 carbonic acid dimethyl ester 
• 634-97-9 pyrrole-2-carboxyl acid 
• 190783-99-4 (S)-methyl 1-methyl-5-oxopyrrolidine-2-carboxylate 

Downstream Products

• 113398-02-0 1-methyl-1H-pyrrole-2-carboxylic acid hydrazide 
• 13138-76-6 1-methyl-4-nitropyrrole-2-carboxylic acid methyl ester 
• 13138-75-5 N-methyl-5-nitropyrrole-2-carboxylic acid methyl ester 
• 67858-47-3 methyl 4-formyl-1-methyl-1H-pyrrole-2-carboxylate 
• 6973-60-0 1-Methyl-2-pyrrolecarboxylic acid 
• 640285-93-4 1-(1-methyl-1H-pyrrol-2-yl)pent-4-en-1-one 
• 119866-61-4 1-methyl-2-methoxycarbonyl-4-chloropyrrole 
• 1196-08-3 5-chloro-1-methyl-1H-pyrrole-2-carboxylic acid methyl ester 
• 132122-28-2 4-formyl-1-methyl-1H-pyrrole-2-carboxylic acid 
• 1196-07-2 methyl 5-bromo-1-methyl-1H-pyrrole-2-carboxylate 
• 85795-19-3 methyl 4-acetyl-1-methylpyrrole-2-carboxylate 
• 1041644-52-3 C₈H₈N₂O₂ 
• 40740-43-0 methyl 4-cyano-1-methyl-pyrrole-2-carboxylate 
• 1607827-03-1 4-{1-[(4-bromophenyl)carbonyl]-2,5-dimethyl-1H-pyrrol-3-yl}morpholine 

Relevant articles and documents

New synthesis of pyrrole-2-carboxylic and pyrrole-2,5-dicarboxylic acid esters in the presence of iron-containing catalysts

Alkyl 1H-pyrrole-2-carboxylates and dialkyl 1H-pyrrole-2,5-dicarboxylates were synthesized in quantitative yield by reactions of 1H-pyrrole, 2-acetyl-1H-pyrrole, and 1-methyl-1H-pyrrole with carbon tetrachloride and aliphatic alcohols in the presence of iron-containing catalysts. A probable reaction mechanism was proposed, and the rate constants and energies of activation of particular steps were determined on the basis of experimental data.

PYRROLE mTORC INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

Chemoselective dehydrogenative esterification of aldehydes and alcohols with a dimeric rhodium(II) catalyst

Dehydrogenative cross-coupling of aldehydes with alcohols as well as dehydrogentive cross-coupling of primary alcohols to produce esters have been developed using a Rh-terpyridine catalyst. The catalyst demonstrates broad substrate scope and good functional group tolerance, affording esters highly selectively. The high chemoselectivity of the catalyst stems from its preference for dehydrogenation of benzylic alcohols over aliphatic ones. Preliminary mechanistic studies suggest that the active catalyst is a dimeric Rh(ii) species, operating via a mechanism involving metal-base-metal cooperativity.