166266-19-9

Basic information

• Product Name: 5-Iodo-3-methyl-2-pyridinamine
• Synonyms: 2-amino-3-methyl-5-iodopyridine;5-Iodo-3-methylpyridin-2-amine, 2-Amino-5-iodo-3-picoline;2-AMINO-3-METHYL-5-IODOPYRIDINE 98%;5-iodo-3-methyl-2-pyridinylamine;5-iodo-3-methyl-2-pyridinamine (en);(5-iodo-3-methyl-2-pyridyl)amine;2-AMINO-5-IODO-3-METHYLPYRIDINE;2-AMINO-5-IODO-3-PICOLINE
• CAS NO: 166266-19-9
• Molecular Formula: C₆H₇IN₂
• Molecular Weight: 234.04
• Product Categories: Pyridine;Pyridines;Boronic Acid;Heterocycle-Pyridine series;amine| alkyl Iodine
• Mol File: 166266-19-9.mol

Chemical Properties

• Melting Point: 110.2-110.5°C
• Boiling Point: 303.4 °C at 760 mmHg
• Flash Point: 137.3 °C
• Appearance: /
• Density: 1.898 g/cm³
• Vapor Pressure: 0.000935mmHg at 25°C
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: soluble in Methanol
• PKA: 5.22±0.49(Predicted)
• Sensitive: Light Sensitive
• CAS DataBase Reference: 5-Iodo-3-methyl-2-pyridinamine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Iodo-3-methyl-2-pyridinamine(166266-19-9)
• EPA Substance Registry System: 5-Iodo-3-methyl-2-pyridinamine(166266-19-9)

Safety Data

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 166266-19-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
5-Iodo-3-methyl-2-pyridinamine is utilized as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs. Its chemical structure allows for the creation of compounds with specific therapeutic properties, making it an essential component in medicinal chemistry.
Used in Agrochemical Synthesis:
In the agrochemical industry, 5-Iodo-3-methyl-2-pyridinamine is employed as a precursor in the production of various agricultural chemicals. Its incorporation into these products can enhance their effectiveness in pest control and crop protection, thereby contributing to increased agricultural productivity.
Used in Medicinal Chemistry Research:
5-Iodo-3-methyl-2-pyridinamine is also used as a research compound in medicinal chemistry. It aids scientists in understanding the structure-activity relationships of potential drug candidates and in the optimization of their pharmacological profiles.
Used in Industrial Applications:
Beyond its use in pharmaceuticals and agrochemicals, 5-Iodo-3-methyl-2-pyridinamine may find applications in other industries where its unique chemical properties can be leveraged for specific purposes, such as in the development of new materials or chemical processes.

InChI:InChI=1/C6H7IN2/c1-4-2-5(7)3-9-6(4)8/h2-3H,1H3,(H2,8,9)/p+1

Upstream product

• 3430-21-5 5-bromo-3-methyl-pyridin-2-ylamine 
• 1603-40-3 3-methylpyridin-2-ylamine 

Downstream Products

• 930121-92-9 3-methyl-5-(4-(trifluoromethyl)phenyl)pyridin-2-amine 
• 1450622-39-5 2-(2-(4-((6-amino-5-methyl-3-pyridinyl)sulfonyl)phenyl)-5-pyrimidinyl)-1,1,1-trifluoro-2-propanol 
• 1450622-42-0 3-methyl-5-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)sulfonyl)-2-pyridinamine 
• 1450622-41-9 5-((4-bromophenyl)sulfonyl)-3-methyl-2-pyridinamine 
• 1450622-40-8 5-((4-bromophenyl)sulfanyl)-3-methyl-2-pyridinamine 
• 1386977-28-1 (S)-3-(6-amino-5-methylpyridin-3-yl)-4-benzyl-5,5-diphenyloxazolidin-2-one 
• 59782-89-7 2-Chloro-5-iodo-3-methylpyridine 
• 166266-21-3 2-Benzyloxy-5-<3'-<<(1,1-dimethylethyl)diphenylsilyl>oxy>-β-D-glycero-pentofuran-3'-ulos-1'-yl>-3-methylpyridine 
• 166266-27-9 2-(Benzyloxy)-5-(2'-deoxy-β-O-ribofuranosyl)-3-methylpyridine 
• 166266-20-2 2-(Benzyloxy)-5-iodo-3-methylpyridine 
• 289681-53-4 2-[2-(4-nitrophenyl)ethoxy]-5-[5'-O-(4,4'-dimethoxytrityl)-1',2'-dideoxy-β-D-erythro-pentafuranozyl]-3-methylpyridine 
• 289681-50-1 ((2R,5R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-{5-methyl-6-[2-(4-nitro-phenyl)-ethoxy]-pyridin-3-yl}-2,5-dihydro-furan-2-yl)-methanol 

Relevant articles and documents

SULFONYL COMPOUNDS THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN

The present invention relates to sulfonyl compounds that interact with glucokinase regulatory protein. In addition, the present invention relates to methods of treating type 2 diabetes, and other diseases and/or conditions where glucokinase regulatory protein is involved using the compounds, or pharmaceutically acceptable salts thereof, and pharmaceutical compositions that contain the compounds, or pharmaceutically acceptable salts thereof.

Substituted 2H-1,3-benzoxazin-4(3H)-ones

Substituted benzoxazin-4(3H)-ones are provided which are useful for treating thrombosis and for reducing the likelihood and/or severity of a secondary ischemic event in a patient.

Synthesis of a dA-dT base pair analogue and its effects on DNA-ligand binding

Two nucleoside derivatives containing the base analogues 3-deazaadenine and 3-methyl-2-pyridone have been prepared as analogues of dA and dT, respectively. After conversion into the appropriately protected phosphoramidites, DNA sequences were prepared with site-specifically placed analogues. When present in a duplex DNA sequence, the analogues result in the deletion of one or both of the hydrogen bonding functional groups (the N3-nitrogen of dA and the O2-carbonyl of dT) present in the minor groove. Binding by two ligands, 4′,6-diamidine-2-phenyl indole (DAPI) and Hoechst 33258 in the minor groove has been probed using a variety of DNA sequences. These sequences contain a d(GAATTC)2 core with analogue nucleosides substituted for one or more of the dA and dT residues. DAPI bound strongly to any sequence that contained both O2-carbonyls of the central two dT residues. The presence of a dc3A residue did in some cases enhance binding. With one of the central O2-carbonyls deleted, the binding was noticeably reduced, and with both absent, no significant binding could be detected. Similar although less dramatic results were observed with Hoechst 33258 binding to analogue sequences.