- Structure-activity relationships of the antimalarial agent artemisinin. 3. Total synthesis of (+)-13-carbaartemisinin and related tetra- and tricyclic structures
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Provided by total synthesis, endoperoxides 18, 20, and 22 underwent intramolecular oxymercuration-demercuration leading respectively to formation of an isomeric tetracycle, (1aS,3S, 5aS,6R,8aS,9R,125)-10-deoxo-13- carbaartemisinin (19), (+)-10-deoxo-13-ca
- Avery, Mitchell A.,Fan, Pingchen,Karle, Jean M.,Bonk, Jason D.,Miller, Robert,Goins, D. Keith
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- Replacement of the nonperoxidic trioxane oxygen atom of artemisinin by carbon: Total synthesis of (+)-13-carbaartemisinin and related structures
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Provided by total synthesis, endoperoxides 17, 19 and 21 underwent intramolecular oxymercuration-demercuration leading respectively to formation of an isomeric tetracycle, (1aS,3S,5aS,6R,8aS,9R,12S)-10-deoxo-13-carbaartemisinin 18, (+)-10-deoxo-13-carbaar
- Avery, Mitchell A.
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p. 3965 - 3968
(2007/10/02)
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