Discovery of 2′-hydroxychalcones as autophagy inducer in A549 lung cancer cells
A series of 2′-hydroxychalcone derivatives was synthesized and the effects of all the compounds on growth of A549 lung cancer cell were investigated. The results showed that all compounds had inhibitory effects on the growth of A549 lung cancer cells and compound 2-7 possessed the highest growth inhibitory effect and induced autophagy of A549 lung cancer cells.
SAR Studies and Biological Characterization of a Chromen-4-one Derivative as an Anti- Trypanosoma brucei Agent
Chemical modulation of the flavonol 2-(benzo[d][1,3]dioxol-5-yl)-chromen-4-one (1), a promising anti-Trypanosomatid agent previously identified, was evaluated through a phenotypic screening approach. Herein, we have performed structure-activity relationsh
Borsari, Chiara,Santarem, Nuno,MacEdo, Sara,Jiménez-Antón, María Dolores,Torrado, Juan J.,Olías-Molero, Ana Isabel,Corral, María J.,Tait, Annalisa,Ferrari, Stefania,Costantino, Luca,Luciani, Rosaria,Ponterini, Glauco,Gul, Sheraz,Kuzikov, Maria,Ellinger, Bernhard,Behrens, Birte,Reinshagen, Jeanette,Alunda, José María,Cordeiro-Da-Silva, Anabela,Costi, Maria Paola
supporting information
p. 528 - 533
(2019/04/25)
CDK inhibitors having flavone structure
The present invention relates to a novel flavone derivative, pharmaceutically acceptable salt, hydrate, solvate and isomer thereof which is useful as an inhibitor against Cyclin Dependent Kinase (CDK), a process for preparation thereof, and a composition of anti-cancer agent or agent for treating neurodegenerative disease comprising this compound as an active ingredient.
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(2008/06/13)
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