- Asymmetric Cross [10+2] Cycloadditions of 2-Alkylidene-1-indanones and Activated Alkenes under Phase-Transfer Catalysis
-
Isobenzofulvene species are versatile synthons in organic chemistry, which have been employed in diverse challenging higher-order cycloaddition reactions. Here, the first chemoselective and asymmetric cross [10+2] cycloaddition reaction between activated 2-alkylidene-1-indanones and a variety of electron-deficient alkenes has been developed, relying on the in situ generation of dearomative 1-hydroxyl isobenzofulvene anion intermediates under the catalysis of a newly designed bulky cinchona-derived phase-transfer compound. An array of fused frameworks with multifunctionalities were generally furnished in excellent diastereo- and enantioselectivity, even at 1 mol % catalyst loadings.
- Yang, Yang,Jiang, Ying,Du, Wei,Chen, Ying-Chun
-
supporting information
p. 1754 - 1758
(2020/02/11)
-
- HandaPhos: A General Ligand Enabling Sustainable ppm Levels of Palladium-Catalyzed Cross-Couplings in Water at Room Temperature
-
The new monophosphine ligand HandaPhos has been identified such that when complexed in a 1:1 ratio with Pd(OAc)2, enables Pd-catalyzed cross-couplings to be run using ≤1000 ppm of this pre-catalyst. Applications to Suzuki-Miyaura reactions involving highly funtionalized reaction partners are demonstrated, all run using environmentally benign nanoreactors in water at ambient temperatures.
- Handa, Sachin,Andersson, Martin P.,Gallou, Fabrice,Reilly, John,Lipshutz, Bruce H.
-
supporting information
p. 4914 - 4918
(2016/04/26)
-
- Synthesis and reactivity of an unprecedented osmium(VIII) alkylidene
-
The synthesis of a family of Os(VIII) alkylidene complexes, the highest oxidation state alkylidenes known to date, and their reactivity toward small organic molecules are reported.
- Martin, Véronique,Blakey, Simon
-
supporting information; experimental part
p. 6800 - 6803
(2009/04/06)
-
- Inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT) as hypocholesterolemic agents: Synthesis and structure-activity relationships of novel series of sulfonamides, acylphosphonamides and acylphosphoramidates
-
Sulfoacetic acid, phosphoramidate, and phosphonamide analogs of the ACAT inhibitors, CI-999 and CI-1011 were synthesized. The structure-activity relationships of these compounds as ACAT inhibitors are described.
- Lee,Roark,Picard,Sliskovic,Roth,Stanfield,Hamelehle,Bousley,Krause
-
p. 289 - 294
(2007/10/03)
-
- Phosphonamide ACAT inhibitors
-
The present invention is directed to compounds useful for the regulation of cholesterol of Formula I, methods for using them and pharmaceutical compositions thereof, STR1 wherein Ar and Ar1 are each independently selected from unsubstituted or substituted phenyl which substituents are from 1-5 in number and are each independently selected from alkyl, alkoxy, hydroxy, halogen, nitro, trifluoromethyl, COOH, and COOalkyl; X is --NH--, --O--, --S--, or --(CH2)0-4 --, and R is hydrogen, alkyl, or phenyl.
- -
-
-
- N-acyl sulfamic acid esters (or thioesters), N-acyl sulfonamides, and N-sulfonyl carbamic acid esters (or thioesters) as hypercholesterolemic agents
-
The present invention is directed to compounds useful for the regulation of cholesterol of Formula I, methods for using them and pharmaceutical compositions thereof, STR1 wherein X and Y are oxygen, sulfur, or (CR'R")n wherein n is 1 to 4; R is hydrogen, alkyl, or benzyl; R1 and R2 are phenyl, substituted phenyl, naphthyl, substituted naphthyl, an aralkyl group, an alkyl chain, adamantyl, or a cycloalkyl group.
- -
-
-