16667-45-1

Basic information

• Product Name: 1-(methylamino)propan-2-ol
• Synonyms: 1-(methylamino)propan-2-ol;1-(Methylamino)-2-propanol;2-propanol, 1-(methylamino)-;Einecs 240-712-0;1-(methylamino)-2-propanol(SALTDATA: FREE);1-(Methylamino)-2-propanol HCl;1-(Methylamino)
• CAS NO: 16667-45-1
• Molecular Formula: C₄H₁₁NO
• Molecular Weight: 89.13624
• EINECS: 240-712-0
• Mol File: 16667-45-1.mol

Chemical Properties

• Boiling Point: 148.8°Cat760mmHg
• Flash Point: 67.4°C
• Appearance: /
• Density: 0.88g/cm³
• Vapor Pressure: 1.59mmHg at 25°C
• Refractive Index: 1.42
• PKA: 14.91±0.20(Predicted)
• CAS DataBase Reference: 1-(methylamino)propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(methylamino)propan-2-ol(16667-45-1)
• EPA Substance Registry System: 1-(methylamino)propan-2-ol(16667-45-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 16667-45-1(Hazardous Substances Data)

Usage

Uses

Used in the Preparation of Amphoteric Surfactants:
1-(Methylamino)propan-2-ol is used as a key intermediate in the synthesis of amphoteric surfactants containing polyoxyethylene group chains. These surfactants are valued for their mildness, biodegradability, and foaming properties, making them suitable for use in personal care products, such as shampoos, body washes, and bubble baths.
Used in the Personal Care Industry:
In the personal care industry, 1-(methylamino)propan-2-ol is used as a building block for the development of amphoteric surfactants with polyoxyethylene group chains. These surfactants contribute to the formulation of mild and effective cleansing products, providing a gentle cleansing experience for consumers while maintaining the integrity of the skin's natural barrier.
Used in the Formulation of Eco-friendly Cleaning Products:
1-(Methylamino)propan-2-ol-based amphoteric surfactants are favored for their biodegradability and low environmental impact. They are used in the formulation of eco-friendly cleaning products, such as dishwashing liquids and laundry detergents, that are designed to minimize harm to aquatic life and reduce the overall ecological footprint of household cleaning routines.

InChI:InChI=1/C4H11NO/c1-4(6)3-5-2/h4-6H,3H2,1-2H3

Upstream product

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Downstream Products

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• 176370-13-1 1-(2-hydroxypropyl)-1-methylguanidine 
• 71112-21-5 1-[[2,6-dinitro-4-(trifluoromethyl)phenyl]methylamino]-2-propanol 

Relevant articles and documents

AMINOPYRIDINE COMPOUNDS AND METHODS FOR THE PREPARATION AND USE THEREOF

The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis, including its proteases arginine gingipain A/B (Rgp), and their use for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease. In certain embodiments, the invention provides compounds according to Formula I and Formula III, as described herein, and pharmaceutically acceptable salts thereof.

HEPATITIS B ANTIVIRAL AGENTS

The present invention includes a method of inhibiting, suppressing or preventing HBV infection in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of at least one compound of the invention.

Process for the continuous preparation of hydroxyalkylamides

Process for the continuous preparation of hydroxyalkylamides Process for the continuous preparation of hydroxyalkylamides from carboxylic esters and alkanolamines, wherein the reaction of the starting materials is carried out in an extruder or intensive mixer by intensive mixing and brief reaction with supply of heat and simultaneous removal of the alcohol formed and the final product is then isolated.

OXAZOLIDINES. 1. BASIC CATALYTIC DISPROPORTIONATION OF CYCLOHEXANOSPIRO-2-OXAZOLIDINES: SYNTHESIS OF N-SUBSTITUTED 4,5,6,7-TETRAHYDROINDOLES

It has been shown that the basic catalytic disproportionation of cyclohexanospiro-2-oxazolidines in the presence of potasium hydroxide or sodium methylate leads to N-substituted 4,5,6,7-tetrahydroindoles with a yield of up to 73percent.The influence of the character of substituents at the nitrogen atom of oxazolidine on the course of the reaction has been established.

Further Studies on a Site-specific Hydrogen Transfer Observed in Electron Capture Negative Ion Chemical Ionization Mass Spectrometry of Hydroxyamine Pentafluoropropionate Derivatives

Further studies have demonstrated that the site-specific hydrogen transfer process involved in the formation of the m/z 145 anion of β-hydroxyamine pentafluoropropionate (PFP) derivatives observed under electron capture negative ion chemical ionization conditions occurs when the two functional groups are separated by up to five carbon atoms.Deuterium labelling has established that the site specificity, transfer of a hydrogen atom from the carbon adjacent to nitrogen to the OPFP group, is maintained in 4-amino-butan-1-ol-N,O-(PFP)2.The corresponding PFP derivatives of the N-methylaminoalkanol- (PFP)2 derivatives lack the m/z 145 species with m/z 163, -, being the base anion.Substitution of alkyl groups on the carbon adjacent to oxygen results in a diminution of the ion intensity at m/z 145 with a marked increase in the intensity of m/z 144.The formation of the m/z 145 and 144 anions is proposed to proceed through the intervention of a fluoride ion-molecule complex as outlined in Scheme 1 with the product ion distribution dependent on which of the two pathways is preferred.