166762-90-9

Basic information

• Product Name: O-[(Guanin-9-yl)Methyl] Acyclovir
• Synonyms: O-[(Guanin-9-yl)Methyl] Acyclovir;Acyclovir Impurity J: 9,9'-[Ethylene-bis(oxymethylene)] Bis (2-amino-1-9-dihydro-6H-purin-6-one);Acyclovir Dimer Impurity(Impurity J)
• CAS NO: 166762-90-9
• Molecular Formula: C14H16N10O4
• Molecular Weight: 388.34144
• Product Categories: Heterocycles, Impurities, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 166762-90-9.mol

Chemical Properties

• Appearance: /
• Density: 1.99±0.1 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Aqueous Base (Slightly), DMSO (Slightly, Heated)
• PKA: 9.04±0.20(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: O-[(Guanin-9-yl)Methyl] Acyclovir(CAS DataBase Reference)
• NIST Chemistry Reference: O-[(Guanin-9-yl)Methyl] Acyclovir(166762-90-9)
• EPA Substance Registry System: O-[(Guanin-9-yl)Methyl] Acyclovir(166762-90-9)

Safety Data

• Hazardous Substances Data: 166762-90-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
O-[(Guanin-9-yl)Methyl] Acyclovir is used as a dimer impurity in the production of the antiviral agent Acyclovir (A192400) for the treatment of viral infections. It is important to monitor and control the presence of this impurity in the final product to ensure the safety and efficacy of the medication.
Used in Research and Development:
O-[(Guanin-9-yl)Methyl] Acyclovir can be used as a research compound to study its properties, interactions, and potential applications in the field of virology and antiviral drug development. Understanding the behavior of this dimer impurity can provide valuable insights into the synthesis, formulation, and optimization of Acyclovir and other antiviral agents.
Used in Quality Control and Regulatory Compliance:
O-[(Guanin-9-yl)Methyl] Acyclovir is used as a reference material in the quality control and regulatory compliance processes for the manufacturing of Acyclovir. It helps in the development and validation of analytical methods, such as high-performance liquid chromatography (HPLC) or other chromatographic techniques, to accurately quantify and control the levels of impurities in the final drug product.

Upstream product

• 1417988-85-2 N-{9-[2-(2-acetylamino-6-oxo-1,6-dihydropurin-9-ylmethoxy)-ethoxymethyl]-6-oxo-6,9-dihydro-1H-purin-2-yl}acetamide 

Relevant articles and documents

Synthesis of 9,9'-[1,2-Ethanediylbis(oxymethylene)]bis-2-amino- 1,9-dihydro-6H-purin-6-one, an impurity of acyclovir

The synthesis of 9,9'-[1,2-ethanediylbis(oxymethylene)]bis-2-amino-1,9- dihydro- 6H-purin-6-one, a minor impurity of acyclovir, is described. Starting with commercial N-(9-acetyl-6-oxo-1H-purin-2-yl)acetamide, the process uses an acid catalysed phase transfer catalysis (PTC) process to produce the selective alkylation at the 9 position of the guanine ring.