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16679-95-1

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An efficient, stereocontrolled and versatile synthetic route to bicyclic partially saturated privileged scaffolds
Herein, we describe the development of a simple, high yielding and stereocontrolled strategy for the synthesis of a series of triazolopiperazines and other biologically relevant fused scaffolds from optically active amino acids. This route was applied to the synthesis of 22 scaffolds containing new, previously inaccessible vectors and used to access a novel analogue of ganaplacide.
Bond, Andrew D.,Hanby, Abigail R.,King, Thomas A.,Moss, Thomas A.,Sore, Hannah F.,Spring, David R.,Stewart, Hannah L.
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p. 6818 - 6821
(2020/07/04)

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Chemical Properties

Melting Point: 220 °C
Boiling Point: 650.4°C at 760 mmHg
Flash Point:347.2°C
Density: 1.3g/cm³
Storage Temp.:-15°C
Vapor Pressure: 1.62E-17mmHg at 25°C
Refractive Index: 1.616
PKA: 9.81±0.15(Predicted)
PSA: 113.68000
LogP: 2.70170

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