- Novel synthetic approaches to (Trifluoromethyl)triazoles
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New synthetic procedures for the trifluoromethyl-substituted triazoles, 3-(trifluoromethyl)-4H-1,2,4-triazole and 4-(trifluoromethyl)-1H-1,2,3-triazole, have been elaborated. The target compounds were prepared from commercially available trifluoroacethydr
- Sibgatulin, Dmytriy A.,Bezdudny, Andrii V.,Mykhailiuk, Pavel K.,Voievoda, Nataliia M.,Kondratov, Ivan S.,Volochnyuk, Dmitry M.,Tolmachev, Andrey A.
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- Synthesis of N-unsubstituted 1,2,3-triazoles via a cascade including propargyl azides, allenyl azides, and triazafulvenes
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About thirty NH-1,2,3-triazoles with at least one additional functional group in a side chain at C-4 were prepared from propargyl substrates. These reactions included propargyl azides and their [3,3]-sigmatropic rearrangement to generate short-lived allenyl azides, which cyclized to form triazafulvenes that could be trapped by addition of N- or O-nucleophiles. In most cases, simple substrates and cheap sodium azide were utilized as starting compounds, and the syntheses were performed by using a one-pot procedure without isolation of any dangerous azides. This method to prepare NH-1,2,3-triazoles turned out to be compatible with quite different substitution patterns of the propargyl substrate.
- Banert, Klaus,Hagedorn, Manfred,Hemeltjen, Claudia,Ihle, Andreas,Weigand, Kevin,Priebe, Hanno
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p. 338 - 361
(2016/11/21)
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- TRIAZOLE COMPOUNDS AS LIPOXYGENASE INHIBITORS
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There is provided compounds of formula (I) wherein W is an optionally substituted aryl or heteroaryl group, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a lipoxygenase (e.g. 15- lipoxygenase) is desired and/or required, and particularly in the treatment of inflammation.
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Page/Page column 38
(2008/06/13)
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- TRANSFORMATIONS OF SUBSTITUTED 5-AMINOPYRIMIDINES UNDER CONDITIONS OF THE DIAZOTIZATION
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Reaction of nitrous acid with 4-substituted and 4,6-disubstituted 5-aminopyrimidines Ia-In produces 4-substituted and 4,5-disubstituted 1,2,3-triazoles IIa-IIv, resp.Under similar conditions, 2,5-diaminopyrimidines XIIa-XIId give N(7)-oxides of 2-amino-4-aralkylthiopyrimido-1,2,3-triazines XIIIa-XIIId, and 5-amino-4-chloropyrimidines In and X give 2-diazocyanoacetamides XIa and XIb, resp.Also described are syntheses of 5-formylaminopyrimidines XVa-XVg from glycine ethyl ester via sodium salt XVI.
- Nemeryuk, Michal P.,Sedov, Andrej L.,Safonova, Tamara S.,Cerny, Antonin,Krepelka, Jiri
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p. 215 - 233
(2007/10/02)
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- 1-,2-,and 3-N,N-dialkylcarbamyl-1-H-1,2,3-triazoles
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A compound having the structural formula STR1 wherein X is hydrogen or bromine; Y is bromine, phenyl, C1 -C4 alkyl or C4 -C6 cycloalkyl; R1 and R2 independently are C1 -C6 alkyl or R1 and R2 together form a ring with the nitrogen to which they are attached having 3-8 carbon atoms, optionally substituted with one or two methyl groups.
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