16681-70-2

Basic information

• Product Name: 1,2,3-TRIAZOLE-4-CARBOXYLIC ACID
• Synonyms: 1H-1,2,3-TRIAZOLE-4-CARBOXYLIC ACID;1,2,3-TRIAZOLE-4-CARBOXYLIC ACID;3H-[1,2,3]TRIAZOLE-4-CARBOXYLIC ACID;1H-1,2,3-Triazole-5-carboxylic acid;5-Carboxy-1,2,3-triazole;2H-1,2,3-triazole-4-carboxylic acid();1,2,3-TRIAZOLE-5-CARBOXYLIC ACID;2H-triazole-4-carboxylic acid
• CAS NO: 16681-70-2
• Molecular Formula: C₃H₃N₃O₂
• Molecular Weight: 113.07
• Mol File: 16681-70-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 213 °C(Solv: water (7732-18-5))
• Boiling Point: 446.2 °C at 760 mmHg
• Flash Point: 223.7 °C
• Appearance: /
• Density: 1.694 g/cm³
• Vapor Pressure: 9.57E-09mmHg at 25°C
• Refractive Index: 1.631
• Storage Temp.: 2-8°C
• PKA: pK1:3.22;pK2:8.73 (25°C)
• CAS DataBase Reference: 1,2,3-TRIAZOLE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3-TRIAZOLE-4-CARBOXYLIC ACID(16681-70-2)
• EPA Substance Registry System: 1,2,3-TRIAZOLE-4-CARBOXYLIC ACID(16681-70-2)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 16681-70-2(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of the American Chemical Society, 76, p. 4933, 1954 DOI: 10.1021/ja01648a051

InChI:InChI=1/C3H3N3O2/c7-3(8)2-1-4-6-5-2/h1H,(H,7,8)(H,4,5,6)

Upstream product

• 471-25-0 Propiolic acid 
• 1012040-41-3 4-(methoxymethyl)-1H-1,2,3-triazole 
• 16681-68-8 1H-1,2,3-triazole-4⁽⁵⁾-carbaldehyde 
• 27808-16-8 4-methyl-1H-(1,2,3)-triazole 
• 4967-77-5 methyl 1,2,3-triazole-4-carboxylate 
• 53897-99-7 1H-1,2,3-triazole-4-carboxamide 

Downstream Products

• 288-36-8 1,2,3-triazole 
• 105020-38-0 methyl 1-methyl-1H-1,2,3-triazole-5-carboxylate 
• 105020-39-1 2-Methyl-1,2,3-triazol-4-carbonsaeure-methylester 
• 15294-81-2 4,5-Dibromo-1H-1,2,3-triazole 

Relevant articles and documents

Novel synthetic approaches to (Trifluoromethyl)triazoles

New synthetic procedures for the trifluoromethyl-substituted triazoles, 3-(trifluoromethyl)-4H-1,2,4-triazole and 4-(trifluoromethyl)-1H-1,2,3-triazole, have been elaborated. The target compounds were prepared from commercially available trifluoroacethydr

TRIAZOLE COMPOUNDS AS LIPOXYGENASE INHIBITORS

There is provided compounds of formula (I) wherein W is an optionally substituted aryl or heteroaryl group, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a lipoxygenase (e.g. 15- lipoxygenase) is desired and/or required, and particularly in the treatment of inflammation.

TRANSFORMATIONS OF SUBSTITUTED 5-AMINOPYRIMIDINES UNDER CONDITIONS OF THE DIAZOTIZATION

Reaction of nitrous acid with 4-substituted and 4,6-disubstituted 5-aminopyrimidines Ia-In produces 4-substituted and 4,5-disubstituted 1,2,3-triazoles IIa-IIv, resp.Under similar conditions, 2,5-diaminopyrimidines XIIa-XIId give N(7)-oxides of 2-amino-4-aralkylthiopyrimido-1,2,3-triazines XIIIa-XIIId, and 5-amino-4-chloropyrimidines In and X give 2-diazocyanoacetamides XIa and XIb, resp.Also described are syntheses of 5-formylaminopyrimidines XVa-XVg from glycine ethyl ester via sodium salt XVI.