- 3-phenyl-1-methylenedioxyphenyl-indane-2-carboxylic acid derivatives
-
PCT No. PCT/US96/18465 Sec. 371 Date Feb. 4, 1997 Sec. 102(e) Date Feb. 4, 1997 PCT Filed Nov. 8, 1996 PCT Pub. No. WO97/17341 PCT Pub. Date May 15, 1997Invented is an improved process for preparing aromatic ring-fused cyclopentane derivatives. Preferred compounds prepared by this invention are indane carboxylates and cyclopentanopyridine derivatives. The most preferred compounds prepared by this invention are (+)(1S,2R,3S)-3-[2-(2-hydroxyeth-1-yloxy)-4-methoxyphenyl]-1-(3,4-methylenedioxyphenyl)-5-(prop-1-yloxy)indane-2-carboxylic acid and pharmaceutically acceptable salts thereof and (+)(1S,2R,3S)-3-(2-carboxymethoxy-4-methoxyphenyl)-1-(3,4-methylenedioxypheyl)-5-(prop-1-yloxy)indane-2-carboxylic acid and pharmaceutically acceptable salts thereof. Also invented are novel intermediates useful in preparing these compounds.
- -
-
-
- Stereoselective synthesis of endothelin receptor antagonists
-
PCT No. PCT/US96/18084 Sec. 371 Date May 8, 1998 Sec. 102(e) Date May 8, 1998 PCT Filed Nov. 8, 1996 PCT Pub. No. WO97/17071 PCT Pub. Date May 15, 1997The present invention is directed to a synthetic route for preparing endothelium receptor antagonists of formulae (7B) and (7A) and to the chiral intermediates
- -
-
-
- Stereoselective synthesis of endothelin receptor antagonists
-
The present invention is directed to chiral intermediates in a synthetic route for preparing endothelium receptor antagonists of formulae (7B) and (7A). STR1
- -
-
-
- Endothelin receptor antagonists
-
Novel indane and indene derivatives are described which are endothelin receptor antagonists.
- -
-
-