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2,6-Bis(benzyloxy)-3-bromopyridine is an organic compound characterized by its pyridine ring structure, featuring two benzyloxy groups at the 2nd and 6th positions and a bromine atom at the 3rd position. 2,6-Bis(benzyloxy)-3-bromopyridine is known for its potential applications in various fields due to its unique chemical properties.

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  • 16727-47-2 Structure
  • Basic information

    1. Product Name: 2,6-Bis(benzyloxy)-3-bromopyridine
    2. Synonyms: 2,6-Bis(benzyloxy)-3-bromopyridine
    3. CAS NO:16727-47-2
    4. Molecular Formula: C19H16BrNO2
    5. Molecular Weight: 370
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 16727-47-2.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 455.4±40.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.380±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: Room temperature.
    8. Solubility: N/A
    9. PKA: 0.22±0.34(Predicted)
    10. CAS DataBase Reference: 2,6-Bis(benzyloxy)-3-bromopyridine(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2,6-Bis(benzyloxy)-3-bromopyridine(16727-47-2)
    12. EPA Substance Registry System: 2,6-Bis(benzyloxy)-3-bromopyridine(16727-47-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 16727-47-2(Hazardous Substances Data)

16727-47-2 Usage

Uses

Used in Pharmaceutical Research:
2,6-Bis(benzyloxy)-3-bromopyridine is used as a reagent for studying bacterial oxidation of nicotine. Its application in this field is significant as it aids in understanding the metabolic pathways and enzymatic processes involved in nicotine degradation, which can be crucial for developing new strategies to combat nicotine addiction and related health issues.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2,6-Bis(benzyloxy)-3-bromopyridine can be utilized as a building block or intermediate for the development of more complex molecules with potential applications in various industries, such as pharmaceuticals, agrochemicals, and materials science. Its unique structure allows for further functionalization and modification, making it a valuable compound for synthetic chemists.
Used in Analytical Chemistry:
2,6-Bis(benzyloxy)-3-bromopyridine can also be employed in analytical chemistry as a reference compound or standard for the development and validation of analytical methods, such as high-performance liquid chromatography (HPLC), gas chromatography (GC), and mass spectrometry (MS). Its distinct chemical properties and structural features make it suitable for these purposes, contributing to the advancement of analytical techniques and methodologies.

Check Digit Verification of cas no

The CAS Registry Mumber 16727-47-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,7,2 and 7 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 16727-47:
(7*1)+(6*6)+(5*7)+(4*2)+(3*7)+(2*4)+(1*7)=122
122 % 10 = 2
So 16727-47-2 is a valid CAS Registry Number.

16727-47-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,6-Bis(benzyloxy)-3-bromopyridine

1.2 Other means of identification

Product number -
Other names 3-bromo-2,6-bis(phenylmethoxy)pyridine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:16727-47-2 SDS

16727-47-2Downstream Products

16727-47-2Relevant articles and documents

CEREBLON BINDING COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH

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Paragraph 0245; 0257, (2022/01/08)

Provided herein are piperidine dione compounds having the following structure: wherein R1, R2, R3, R4, L, V, X, a and m are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.

PROTEIN TYROSINE PHOSPHATASE DEGRADERS AND METHODS OF USE THEREOF

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, (2021/06/26)

Provided herein are compounds, compositions, and methods useful for degrading protein tyrosine phosphatase, e.g., protein tyrosine phosphatase non-receptor type 2 (PTPN2) and/or protein tyrosine phosphatase non-receptor type 1 (PTPN1), and for treating related diseases favorably responsive to PTPN1 or PTPN2 inhibitor treatment, e.g., a cancer 5 or a metabolic disease.

BRAF DEGRADERS

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, (2022/02/06)

Present invention provides compounds that cause specifically the degradation of BRAF. The present compounds are useful for the treatment of various cancers.

BIFUNCTIONAL COMPOUNDS FOR THE TREATMENT OF CANCER

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Page/Page column 57; 102; 103, (2021/05/07)

The invention provides bifunctional compounds of formula (I) or a pharmaceutically acceptable salt thereof. Formula (I). The compounds cause the degradation of SMARCA2 via the targeted ubiquination of SMARCA2 protein and subsequent proteasomal degradation and are thus useful for the treatment of cancer. The targeting ligand is of formula (TL).

N/O-LINKED DEGRONS AND DEGRONIMERS FOR PROTEIN DEGRADATION

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Page/Page column 284; 285, (2019/01/10)

This invention provides Degronimers that have E3 Ubiquitin Ligase targeting moieties (Degrons) that can be linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation. The invention also provides Degrons that can be used to treat disorders mediated by cereblon or an Ikaros family protein, and methods of use and compositions thereof as well as methods for their preparation.

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