- Synthesis and identification of an important metabolite of AKB-48 with a secondary hydroxyl group on the adamantyl ring
-
Studies on the metabolism of bioactive substances containing the adamantyl moiety have shown that hydroxylation is likely to occur at a tertiary carbon of adamantane. Herein, we report the synthesis and identification of one major metabolite of AKB-48, a new illicit psychoactive substance with a hydroxyl group at a secondary carbon of the adamantyl ring.
- Wallgren, Jakob,Vikingsson, Svante,Johansson, Anders,Josefsson, Martin,Green, Henrik,Dahlén, Johan,Wu, Xiongyu,Konradsson, Peter
-
-
Read Online
- Synthetic approaches to physiologically active polycyclic compounds: III. Ritter reaction with ketones of the adamantane and oxahomoadamantane series
-
Some previously unknown acetamino derivatives were synthesized by the Ritter reaction from ketones of the adamantane and oxahomoadamantane series. The presence of a hydroxy group as substituent in adamantan-2-one gives rise to formation of acetamino derivatives as products of replacement of the hydroxy group and transformation of the carbonyl group.
- Averina,Borisova,Zefirova,Selyunina,Zyk,Zefirov
-
-
Read Online
- Ring-fused compound, pharmaceutical composition containing same and application of compound
-
The invention discloses a ring-fused compound, a preparation method thereof, pharmaceutical composition containing the compound and an application of the compound. A polycyclic compound (I) as well asan isomer, a prodrug, a stable isotopic derivative or pharmacologically acceptable salt of the compound (I) has the following structure. The polycyclic compound has good IDO1 and/or TDO2 inhibition functions, can effectively treat, relieve and/or prevent various diseases which are related with IDO1 and/or TDO2, such as cancer, virus infection, autoimmune diseases or the like.
- -
-
-