16796-52-4

Basic information

• Product Name: 3-Bromobenzamidine hydrochloride
• Synonyms: 3-BROMOBENZAMIDINE HYDROCHLORIDE;3-bromobenzimidamide hydrochloride;3-Bromobenzimidamide, HCl;3-BROMOBENZAMIDINE HYDROCHLORIDE, 95+%;Benzamidine, m-bromo-, monohydrochloride;Benzenecarboximidamide,3-bromo-, hydrochloride
• CAS NO: 16796-52-4
• Molecular Formula: C₇H₇BrN₂*ClH
• Molecular Weight: 235.51
• Product Categories: blocks;BuildingBlocks;Phenyls & Phenyl-Het;Phenyls & Phenyl-Het
• Mol File: 16796-52-4.mol

Chemical Properties

• Melting Point: 129-131 °C
• Boiling Point: 307.3 °C at 760 mmHg
• Flash Point: 139.6 °C
• Appearance: /
• Vapor Pressure: 0.000544mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 3-Bromobenzamidine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromobenzamidine hydrochloride(16796-52-4)
• EPA Substance Registry System: 3-Bromobenzamidine hydrochloride(16796-52-4)

Safety Data

• Hazardous Substances Data: 16796-52-4(Hazardous Substances Data)

Usage

Chemical Properties

off-white to white powder

InChI:InChI=1/C7H7BrN2.ClH/c8-6-3-1-2-5(4-6)7(9)10;/h1-4H,(H3,9,10);1H

Upstream product

• 56108-13-5 methyl 3-bromobenzenecarboximidoate hydrochloride 
• 6952-59-6 3-cyanobromobenzene 

Downstream Products

• 97582-65-5 5-(3-bromophenyl)<1,2,4->triazolo<1,5-c>pyrimidin-2-amine 
• 97626-36-3 5-(3-ethynylphenyl)<1,2,4>triazolo<1,5-c>pyrimidin-2-amine 
• 97603-48-0 [2-(3-Bromo-phenyl)-pyrimidin-4-yl]-hydrazine 
• 97604-15-4 2-(3-Bromo-phenyl)-4-chloro-pyrimidine 
• 97604-03-0 2-(3-bromophenyl)-4(1H)-pyrimidinone 

Relevant articles and documents

Silver-catalyzed [3+2+1] annulation of aryl amidines with benzyl isocyanide

A silver-catalyzed [3+2+1] annulation of amidines with benzyl isocyanide toward 2,4-diaryl-1,3,5-triazines was developed. A variety of symmetrical and unsymmetrical products were obtained in moderate to good yields. This work also features an oxidant-free approach to 2,4-disubstituted triazines.

A continuous flow synthesis and derivatization of 1,2,4-thiadiazoles

A continuous flow process is presented that enables the efficient synthesis and derivatization of 1,2,4-thiadiazole heterocycles. Special attention was given to the safe handling of the versatile yet hazardous trichloromethane sulfenylchloride reagent including its in-line quenching in order to eliminate malodourous and corrosive by-products. Based on this flow method gram quantities of 5-chloro-3-phenyl-1,2,4-thiadiazole were safely prepared allowing for further elaboration of this valuable building block by reaction with different nitrogen-, sulfur- and oxygen-based nucleophiles. This synthetic approach was subsequently applied to generate a series of bromophenyl-5-chloro-1,2,4-thiadiazoles providing a valuable entry towards further structural diversification on this important heterocyclic scaffold.

5-ETHYLIMIDAROTRIAZONES

The invention relates to novel 5-ethyl-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases.

Novel heterocycles 3

The invention relates to 7-(4-tert butyl-cyclohexyl)-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases.

Preparation of Triazolopyrimidines as Potential Antiasthma Agents

With the use of the human basophil histamine release assay, 5-aryl-2-aminotriazolopyrimidines were found to be active as mediator release inhibitors.These compounds were prepared by reacting arylamidines with sodium ethyl formylacetate or with ethyl propiolate to give pyrimidinones.Treatment with phosphorus oxychloride gave a chloropyrimidine, which was converted to a hydrazinopyrimidine with hydrazine.Cyclization, using cyanogen bromide, gave the triazolopyrimidines, after a Dimroth rearrangement.Following a structure-activity evaluation, the5--2-amino (8-10), 5-(3-bromophenyl)-2-amino (8-13), 5--2-amino (8-11), and 5-(4-pyridinyl)-2-amino (6-7) compounds were found to have the best activity.They were chosen for further pharmacological and toxicological study.