3-Bromobenzamidine hydrochloride

Base Information

• Chemical Name: 3-Bromobenzamidine hydrochloride
• CAS No.: 16796-52-4
• Molecular Formula: C7H7BrN2^.HCl
• Molecular Weight: 235.511
• Hs Code.: 2925290090
• Mol file: 16796-52-4.mol

Synonyms:Benzamidine,m-bromo-, monohydrochloride (8CI);Benzenecarboximidamide, 3-bromo-,monohydrochloride (9CI);3-Bromobenzamidine hydrochloride;3-Bromobenzamidinemonohydrochloride;

Chemical Property of 3-Bromobenzamidine hydrochloride

Chemical Property:

• Vapor Pressure: 0.000544mmHg at 25°C
• Melting Point: 129-131 °C
• Boiling Point: 307.3 °C at 760 mmHg
• Flash Point: 139.6 °C
• PSA: 49.87000
• LogP: 3.33520
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

3-BromobenzamidineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Bromobenzamidine hydrochloride

There total 2 articles about 3-Bromobenzamidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

3-cyanobromobenzene (6952-59-6) → 3-bromobenzene-1-carboximidamide hydrochloride (16796-52-4)

Guidance literature:

3-cyanobromobenzene; With sodium hexamethyldisilazane; In tetrahydrofuran; at 20 ℃; for 1h;

With hydrogenchloride; In water;

DOI:10.1016/j.bmc.2017.01.022

Reference yield:

methyl 3-bromobenzenecarboximidoate hydrochloride (56108-13-5) → 3-bromobenzene-1-carboximidamide hydrochloride (16796-52-4)

Guidance literature:

With ammonia; In ethanol; at 0 ℃; for 96h;

DOI:10.1021/jm00166a023

Reference yield: 85.0%

3-bromobenzene-1-carboximidamide hydrochloride (16796-52-4) + 4-Phenylbenzaldehyde (3218-36-8) → C27H17Br2N3

Guidance literature:

With copper diacetate; sodium carbonate; In toluene; at 110 ℃; for 30h; Reagent/catalyst;

upstream raw materials:

methyl 3-bromobenzenecarboximidoate hydrochloride

3-cyanobromobenzene

Downstream raw materials:

2-(3-bromophenyl)-4(1H)-pyrimidinone

2-(3-Bromo-phenyl)-4-chloro-pyrimidine

[2-(3-Bromo-phenyl)-pyrimidin-4-yl]-hydrazine

5-(3-ethynylphenyl)<1,2,4>triazolo<1,5-c>pyrimidin-2-amine

Refernces

• 1、 Baumann, Marcus,Baxendale, Ian R.. "A continuous flow synthesis and derivatization of 1,2,4-thiadiazoles". . p. 6218 - 6223. Retrieved 2017/09/30.
• 2、 -. "Novel heterocycles 3". . . Retrieved 2008/06/13.