169059-15-8

Basic information

• Product Name: C₁₈H₁₇BrN₄OS₂
• CAS NO: 169059-15-8
• Molecular Weight: 449.395
• Mol File: 169059-15-8.mol

Chemical Properties

• CAS DataBase Reference: C₁₈H₁₇BrN₄OS₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₁₇BrN₄OS₂(169059-15-8)
• EPA Substance Registry System: C₁₈H₁₇BrN₄OS₂(169059-15-8)

Safety Data

• Hazardous Substances Data: 169059-15-8(Hazardous Substances Data)

Upstream product

• 169058-49-5 C₁₁H₁₃N₃OS 
• 1985-12-2 4-Bromophenyl isothiocyanate 
• 76273-51-3 ethyl 3,7-dimethyl-4H-benzo[b][1,4]thiazine-2-carboxylate 
• 23451-96-9 2-amino-5-methylthiophenol 

Downstream Products

• 169058-83-7 C₁₈H₁₅BrN₄OS 
• 169058-66-6 C₁₈H₁₅BrN₄S₂ 

Relevant articles and documents

A facile and green synthesis of "5-(3-methyl-7-substituted-4H-1, 4-benzothiazin-2-yl)-4-aryl-4H-1, 2, 4-triazole-3-thiols" under ultrasound irradiation

A series of novel 3-methyl-7-substituted-4H-1, 4-benzothiazine-2- carbohydrazide & corresponding thiosemicarbazide have been synthesized. The 1, 4-benzothiazine thiosemicarbazides i.e. 2-[(3-methyl-7-substituted-4H-1, 4-benzothiazin-2-yl) carbonyl]-N-aryl-hydrazine carbothiamide when cyclised with 2N sodium hydroxide via intramolecular dehydrative cyclisation gave benzothiazonyl triazoles. The given procedure is in 4-steps. The final step is an intramolecular cyclisation is achieved by ultrasound irradiation & also by conventional method. In general, substantial improvement in rates and increase in modest yields observed when reactions are carried out under sonication, compared with classical heating method. The structures of these compounds have been elucidated by spectral (IR, 1H NMR) analysis.

Synthesis and antimicrobial activity of some new 1, 4-benzothiazine containing thiosemicarbazides and 1, 3, 4-oxadiazole derivatives

A series of novel 3- methyl-7-substituted-4H-1,4-benzothiazine-2- carbohydrazide (3a-e) and corresponding thiosemicarbazides (4-a-q); 2-[3-methyl-7-substituted- 4H -1, 4-benzothiazine-2-yl]-N-(aryl) hydrazine carbothiamide have been synthesized. The thiosemicarbazide when cyclized with iodine via intramolecular cyclisation gave benzothiazonyl oxadiazoles (5-a-q); 5-(3-methyl -7-substitued-4H- 1,4-benzothiazin-2-yl)- N -aryl- 1,3,4- oxadiazol -2-amine and the compounds were tested for antibacterial and antifungal activities against different microorganisms.