- Synthesis of 2-Monochloropanol Fatty Acid Esters and Their Acute Oral Toxicities in Swiss Mice
-
A novel synthetic route was designed, developed, and utilized to synthesize six high-purity 2-monochloropropanediol fatty acid esters (2-MCPD esters), a group of potential processing-induced food contaminants. A chlorine atom was introduced to C-2 of a diethyl malonate molecule, which was reduced by NaBH4 and followed by esterification using fatty acids. The reaction products were isolated and purified using silica gel columns to obtain three 2-MCPD monoesters and three diesters at about 50-54% and 56-59% yields, respectively. In addition, 2-MCPD monopalmitate and dipalmitate were examined for their acute oral toxicities in Swiss mice. The LD50 values of 2-MCPD mono- and dipalmitate were greater than 5000 mg/kg body weight (BW), along with detectable nephrotoxicity and testicular toxicity. The results of this study may promote future investigation of MCPD ester toxicology and detection.
- Zhang, Zhongfei,Yang, Puyu,Gao, Boyan,Huang, Guoren,Liu, Man,Yu, Liangli Lucy
-
p. 3789 - 3795
(2019/04/10)
-
- Oxicam pro-drugs. Nota 1. Synthesis of some prodrugs of piroxicam and lornoxicam
-
With the aim to improve the bioavilability of piroxicam and lornoxicam, we synthesized the following pro-drugs: enol-ethers, enol-esters, enol-carbonates, by reacting the enolic hydroxyl group on C(4), with suitable reagents (palmitoyl chloride, oleoyl chloride, 2-chloro-1,3-dipalmitine, phosphene). In this first communication we report on the synthesis and properties of obtained compounds.
- Passarotti,Valenti,Grianti
-
p. 161 - 165
(2007/10/02)
-