169471-41-4

Basic information

• Product Name: 1,3-BispalMitoyl-2-chloropropanediol
• Synonyms: 1,3-BispalMitoyl-2-chloropropanediol;1,3-DipalMitoyl-2-chloropropanediol;Hexadecanoic Acid 2-Chloro-1,3-propanediyl Ester
• CAS NO: 169471-41-4
• Molecular Formula: C35H67ClO4
• Molecular Weight: 587.35708
• Product Categories: Glycerols, Fatty Acid Derivatives & Lipids, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 169471-41-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 630.7±35.0 °C(Predicted)
• Appearance: /
• Density: 0.939±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 1,3-BispalMitoyl-2-chloropropanediol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-BispalMitoyl-2-chloropropanediol(169471-41-4)
• EPA Substance Registry System: 1,3-BispalMitoyl-2-chloropropanediol(169471-41-4)

Safety Data

• Hazardous Substances Data: 169471-41-4(Hazardous Substances Data)

Usage

Chemical Properties

1,3-BispalMitoyl-2-chloropropanediol is Off-White to Pale Yellow Solid

Uses

1,3-Dipalmitoyl-2-chloropropanediol is used in the synthesis of some prodrugs of Piroxicam and Lornoxicam to improve their bioavailability.

Upstream product

• 497-04-1 2-chloro-propane-1,3-diol 
• 57-10-3 1-hexadecylcarboxylic acid 
• 502-52-3 hexadecanoic acid, 2-hydroxy-1,3-propanediyl ester 

Relevant articles and documents

Synthesis of 2-Monochloropanol Fatty Acid Esters and Their Acute Oral Toxicities in Swiss Mice

A novel synthetic route was designed, developed, and utilized to synthesize six high-purity 2-monochloropropanediol fatty acid esters (2-MCPD esters), a group of potential processing-induced food contaminants. A chlorine atom was introduced to C-2 of a diethyl malonate molecule, which was reduced by NaBH4 and followed by esterification using fatty acids. The reaction products were isolated and purified using silica gel columns to obtain three 2-MCPD monoesters and three diesters at about 50-54% and 56-59% yields, respectively. In addition, 2-MCPD monopalmitate and dipalmitate were examined for their acute oral toxicities in Swiss mice. The LD50 values of 2-MCPD mono- and dipalmitate were greater than 5000 mg/kg body weight (BW), along with detectable nephrotoxicity and testicular toxicity. The results of this study may promote future investigation of MCPD ester toxicology and detection.