170161-27-0Relevant articles and documents
Structural Differences and Redox Properties of Unsymmetric Diiron PDIxCy Complexes
Hess, Corinna R.,Hofmann, Andreas J.,Jandl, Christian
, p. 499 - 505 (2020)
We present two bimetallic iron complexes, [Fe2(PDIeCy)(OTf)4] (1) and [Fe2(PDIpCy)(THF)(OTf)4] (2) coordinated by an unsymmetric ligand. The new ligand, PDIeCy (PDI = pyridyldiimine; e = ethyl; Cy = cyclam), is
Copper(ii) complexes ofN-propargyl cyclam ligands reveal a range of coordination modes and colours, and unexpected reactivity
Counsell, Andrew J.,Yu, Mingfeng,Shi, Mengying,Jones, Angus T.,Batten, James M.,Turner, Peter,Todd, Matthew H.,Rutledge, Peter J.
, p. 3931 - 3942 (2021)
The coordination chemistry ofN-functionalised cyclam ligands has a rich history, yet cyclam derivatives with pendant alkynes are largely unexplored. This is despite the significant potential and burgeoning application ofN-propargyl cyclams and related com
Dual-Function Polymeric HPMA Prodrugs for the Delivery of miRNA
Peng, Zheng-Hong,Xie, Ying,Wang, Yan,Li, Jing,Oupicky, David
, p. 1395 - 1404 (2017)
An HPMA-based polymeric prodrug of a CXCR4 antagonist, AMD3465 (P-SS-AMD), was developed as a dual-function carrier of therapeutic miRNA. P-SS-AMD was synthesized by a copolymerization of HPMA with a methacrylamide monomer in which the AMD3465 was attached via a self-immolative disulfide linker. P-SS-AMD showed effective release of the parent AMD3465 drug following treatment with intracellular levels of glutathione (GSH). The AMD3465 was released in the cells and exhibited functional CXCR4 antagonism, demonstrated by inhibition of the CXCR4-mediated cancer cell invasion. Due to its cationic character, P-SS-AMD could form polyplexes with miRNA and mediate efficient transfection of miR-200c mimics to downregulate expression of a downstream target ZEB-1 in cancer cells. The combined P-SS-AMD/miR-200c polyplexes showed improved ability to inhibit cancer cell migration when compared with individual treatments. The reported findings validate P-SS-AMD as a dual-function delivery vector that can simultaneously deliver a therapeutic miRNA and function as a polymeric prodrug of CXCR4 antagonist.
Biotin-tagged fluorescent sensor to visualize 'mobile' Zn2+ in cancer cells
Fang, Le,Trigiante, Giuseppe,Kousseff, Christina J.,Crespo-Otero, Rachel,Philpott, Michael P.,Watkinson, Michael
, p. 9619 - 9622 (2018)
A cancer cell-targeting fluorescent sensor has been developed to image mobile Zn2+ by introducing a biotin group. It shows a highly selective response to Zn2+in vitro, no toxicity in cellulo and images 'mobile' Zn2+ specifically in cancer cells. We believe this probe has the potential to help improve our understanding of the role of Zn2+ in the processes of cancer initiation and development.
Tri-N-Boc-tetraazamacrocycle-nucleoside conjugates: Synthesis and anti- HIV activities
Dessolin,Vlieghe,Bouygues,Medou,Quelever,Camplo,Chermann,Kraus
, p. 957 - 968 (1998)
As far as linear N-Boc-polyamines conjugates elicited remarkable anti- HIV activity, the synthesis and anti-HIV properties of cyclic N-Boc- polyamines conjugates such as tetraazamacro-cycle-nucleoside were studied. These new conjugates include an ester linkage between the two moieties. They were synthesized using Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate coupling reagent, in the case of N-alkyl polyazamacrocycle derivatives, or through direct condensation of the acyl chloride derivative with nucleoside in the case of Nacyl polyazamacrocycle compounds. None of the new conjugates presented anti-HIV activity greater than that of the corresponding parent nucleosides.
Covalent attachment of [Ni(alkynyl-cyclam)]2+ catalysts to glassy carbon electrodes
Zhanaidarova, Almagul,Moore, Curtis E.,Gembicky, Milan,Kubiak, Clifford P.
, p. 4116 - 4119 (2018)
Surface modification of glassy carbon electrodes (GCEs) with molecular electrocatalysts is an important step towards developing more efficient heterogeneous CO2 reduction materials. Here, we report direct anodic electrografting of [Ni(alkynyl-cyclam)]2+ catalysts to the surface of GCEs in one simple step using inexpensive earth-abundant chemicals. When modified, these electrodes show reversible electrochemistry in organic solvents with zero peak-to-peak separations (ΔE = 0) and non-diffusive I (V) profiles that are typical for heterogeneous redox materials. CPE of these electrodes showed enhanced formation of H2 gas relative to CO compared to homogeneous catalysts.
Synthesis and evaluation of [99mTc]TcAMD3465 as a SPECT tracer for CXCR4 receptor imaging
Wu, Yitian,Zhu, Hong,Zhang, Xiaojun,Yu, Peng,Gui, Yuan,Xu, Zhihong,Zhang, Jinming,Tian, Jiahe
, p. 627 - 633 (2021)
CXCR4 plays an important role in a number of immunological-based diseases and cancers. The development of radiotracers targeting CXCR4 can provide a valuable tool for the diagnosis and monitoring of conditions involving deregulation of the receptor. The i
A functional model for the cysteinate-ligated non-heme iron enzyme superoxide reductase (SOR)
Kitagawa, Terutaka,Dey, Abhishek,Lugo-Mas, Priscilla,Benedict, Jason B.,Kaminsky, Werner,Solomon, Edward,Kovacs, Julie A.
, p. 14448 - 14449 (2006)
Superoxide reductases (SORs) are cysteine-ligated, non-heme iron enzymes that reduce toxic superoxide radicals (O2-). The functional role of the trans cysteinate, as well as the mechanism by which SOR reduces O2-, is unknown. Herein is described a rare example of a functional metalloenzyme analogue, which catalytically reduces superoxide in a proton-dependent mechanism, via a trans thiolate-ligated iron-peroxo intermediate, the first example of its type. Acetic-acid-promoted H2O2 release, followed by Cp2Co reduction, regenerates the active Fe(II) catalyst. The thiolate ligand and its trans positioning relative to the substrate are shown to contribute significantly to the catalyst's function, by lowering the redox potential, changing the spin state, and dramatically lowering the νFe-O stretching frequency well-below that of any other reported iron-peroxo, while leaving νO-O high, so as to favor superoxide reduction and Fe-O, as opposed to O-O, bond cleavage. Thus we provide critical insight into the relationship between the SOR structure and its function, as well as important benchmark parameters for characterizing highly unstable thiolate-ligated iron-peroxo intermediates. Copyright
Synthesis of cyclam-capped β-cyclodextrin-bonded silica particles for use as chiral stationary phases in capillary electrochromatography
Gong, Yinhan,Xue, Guoping,Xiang, Yanqiao,Bradshaw, Jerald S,Lee, Milton L,Lee, Hian Kee
, p. 2463 - 2466 (2002)
β-Cyclodextrin (β-CD) was anchored onto silica particles at its C(2) position, derivatized primarily at the C(6) position by treatment with bromoacetyl bromide, and finally reacted with two types of cyclams to form cyclam-capped β-CD-bonded silica particles. When used as chiral stationary phases in capillary electrochromatography, these novel bonded silica particles exhibited excellent enantioselectivities for chiral separations.
Cyclam-Modified PEI for Combined VEGF siRNA Silencing and CXCR4 Inhibition to Treat Metastatic Breast Cancer
Zhou, Yiwen,Yu, Fei,Zhang, Feiran,Chen, Gang,Wang, Kaikai,Sun, Minjie,Li, Jing,Oupicky, David
, p. 392 - 401 (2018)
Chemokine receptor CXCR4 plays an important role in cancer cell invasion and metastasis. Recent findings suggest that anti-VEGF therapies upregulate CXCR4 expression, which contributes to resistance to antiangiogenic therapies. Here, we report the develop
