170278-50-9

Basic information

• Product Name: N-Succinimidyl 3-(Diphenylphosphino)propionate
• Synonyms: N-Succinimidyl 3-(Diphenylphosphino)propionate;3-(Diphenylphosphino)propionic Acid N-Succinimidyl Ester;2,5-Pyrrolidinedione, 1-[3-(diphenylphosphino)-1-oxopropoxy]-;N-Succinimidyl 3-(diphenylphosphino)propanoate;N-Succinimidyl 3-(diphenylphosphino)propionate 95%;N-Succinimidyl 3-(Diphenylphosphino)propionate
• CAS NO: 170278-50-9
• Molecular Formula: C19H18NO4P
• Molecular Weight: 355.324281
• Mol File: 170278-50-9.mol

Chemical Properties

• Melting Point: 104-108°C
• Boiling Point: 486.951°C at 760 mmHg
• Flash Point: 248.299°C
• Appearance: /
• Vapor Pressure: 0mmHg at 25°C
• CAS DataBase Reference: N-Succinimidyl 3-(Diphenylphosphino)propionate(CAS DataBase Reference)
• NIST Chemistry Reference: N-Succinimidyl 3-(Diphenylphosphino)propionate(170278-50-9)
• EPA Substance Registry System: N-Succinimidyl 3-(Diphenylphosphino)propionate(170278-50-9)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 170278-50-9(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
N-Succinimidyl 3-(Diphenylphosphino)propionate is used as a reagent for the conversion of azides into the corresponding diazo compounds under mild conditions. This conversion is an important step in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Chemical Research:
In the field of chemical research, N-Succinimidyl 3-(Diphenylphosphino)propionate is used as a reagent to study the reactivity and properties of azides and diazo compounds. This research can lead to the development of new synthetic methods and the discovery of novel compounds with potential applications in various industries.
Used in Pharmaceutical Industry:
N-Succinimidyl 3-(Diphenylphosphino)propionate is used as a reagent in the synthesis of pharmaceutical compounds. The conversion of azides into diazo compounds can be a key step in the production of certain drugs, making this reagent an important tool in the development of new medications.
Used in Agrochemical Industry:
In the agrochemical industry, N-Succinimidyl 3-(Diphenylphosphino)propionate is used as a reagent for the synthesis of agrochemical compounds, such as pesticides and herbicides. The conversion of azides into diazo compounds can be a crucial step in the production of these compounds, contributing to the development of more effective and environmentally friendly products.
Used in Specialty Chemicals Industry:
N-Succinimidyl 3-(Diphenylphosphino)propionate is used as a reagent in the synthesis of specialty chemicals, such as dyes, pigments, and other functional materials. The conversion of azides into diazo compounds can be an essential step in the production of these chemicals, enabling the development of innovative products with unique properties and applications.

InChI:InChI=1/C19H18NO4P/c21-17-11-12-18(22)20(17)24-19(23)13-14-25(15-7-3-1-4-8-15)16-9-5-2-6-10-16/h1-10H,11-14H2

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 2848-01-3 3-(diphenylphosphino)propionic acid 

Relevant articles and documents

Fluorescent and Biocompatible Ruthenium-Coordinated Oligo(p-phenylenevinylene) Nanocatalysts for Transfer Hydrogenation in the Mitochondria of Living Cells

It is challenging to design metal catalysts for in situ transformation of endogenous biomolecules with good performance inside living cells. Herein, we report a multifunctional metal catalyst, ruthenium-coordinated oligo(p-phenylenevinylene) (OPV-Ru), for intracellular catalysis of transfer hydrogenation of nicotinamide adenine dinucleotide (NAD+) to its reduced format (NADH). Owing to its amphiphilic characteristic, OPV-Ru possesses good self-assembly capability in water to form nanoparticles through hydrophobic interaction and π–π stacking, and numerous positive charges on the surface of nanoparticles displayed a strong electrostatic interaction with negatively charged substrate molecules, creating a local microenvironment for enhancing the catalysis efficiency in comparison to dispersed catalytic center molecule (TOF value was enhanced by about 15 fold). OPV-Ru could selectively accumulate in the mitochondria of living cells. Benefiting from its inherent fluorescence, the dynamic distribution in cells and uptake behavior of OPV-Ru could be visualized under fluorescence microscopy. This work represents the first demonstration of a multifunctional organometallic complex catalyzing natural hydrogenation transformation in specific subcellular compartments of living cells with excellent performance, fluorescent imaging ability, specific mitochondria targeting and good chemoselectivity with high catalysis efficiency.

COMPOUNDS THAT INHIBIT MCL-1 PROTEIN

Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

Cyclic decapeptide gramicidin S derivatives containing phosphines: Novel ligands for asymmetric catalysis

The cyclic peptide gramicidin S was used as a rigid template to provide novel peptide-based bisphosphine ligands for transition metal catalysis. Two bisphosphine-coordinated Rh(i) complexes allowed asymmetric hydrogenation with 10-52% ee and the corresponding Pd(ii) analogues catalysed asymmetric allylic alkylation with 13-15% ee. The Royal Society of Chemistry 2013.

Catalytic asymmetric synthesis of trisubstituted aziridines

A method is described which provides for the direct asymmetric catalytic synthesis of trisubstituted aziridines from imines and diazo compounds. While unactivated imines were not reactive to α-diazo carbonyl compounds in which the diazo carbon was disubstituted, N-Boc imines react with both α-diazo esters and α-diazo-N-acyloxazolidinones to give trisubstituted aziridines with excellent diastereo- and enantioselectivities.

PREPARATION OF DIAZO AND DIAZONIUM COMPOUNDS

A method for making diazo-compounds, diazonium salts thereof and other protected forms of these compounds. Diaz-compounds are prepared by reaction of a tertiary phosphine reagent carrying a reactive carbonyl group with an azide. The reaction can also generate an acyl triazene which can be converted thermally or by addition of base to form the diazo-compound or the acyl triazene can be isolated. The method is particularly useful for conversion of azides carrying one or more electron withdrawing groups to diazo-compounds. The method can be carried out in aqueous medium under mild conditions and is particularly useful for conversion of azido sugars to diazo-compound and diazonium salts thereof under physiological conditions. Tertiary phosphine reagents, particularly those that are water-soluble, and precursors for preparation of the reagents are provided.