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N-Hydroxysuccinimide
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High purity N-Hydroxy succinimide with high quality and best price cas:6066-82-6
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N-Hydroxysuccinimide CAS NO.6066-82-6
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6066-82-6 Usage

Uses

Useful in the carbodiimide method for improved amidations and peptide couplings.

Uses

Additive used in the carbodiimide method for improved amidations and peptide couplings.

Chemical Properties

White to pale yellow

Uses

Reagent for preparation of active esters of amino acids.

Purification Methods

Recrystallise the imide from EtOH/ethyl acetate [Manesis & Goodmen J Org Chem 52 5331 1987]. [Beilstein 21/9 V 498.]

Uses

N-hydroxysuccinimide (NHS) is often used to assist carbodiimide-mediated peptide coupling by forming an active ester intermediate via condensation of the surface carboxyl group and NHS. The NHS-reactive ester intermediate is susceptible to nucleophilic attack by primary amines and results in the formation of stable amide bonds between the biomaterial surface and the N-terminus of the peptide.
InChI:InChI=1/C4H5NO3/c6-3-1-2-4(7)5(3)8/h8H,1-2H2

6066-82-6 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (B0249)  N-Hydroxysuccinimide [Coupling Reagent for Peptide]  >98.0%(GC)(T) 6066-82-6 25g 720.00CNY Detail
TCI America (H0623)  N-Hydroxysuccinimide  >98.0%(T) 6066-82-6 25g 220.00CNY Detail
TCI America (H0623)  N-Hydroxysuccinimide  >98.0%(T) 6066-82-6 100g 660.00CNY Detail
TCI America (H0623)  N-Hydroxysuccinimide  >98.0%(T) 6066-82-6 500g 2,300.00CNY Detail
Alfa Aesar (A10312)  N-Hydroxysuccinimide, 98+%    6066-82-6 25g 170.0CNY Detail
Alfa Aesar (A10312)  N-Hydroxysuccinimide, 98+%    6066-82-6 100g 447.0CNY Detail
Alfa Aesar (A10312)  N-Hydroxysuccinimide, 98+%    6066-82-6 500g 1905.0CNY Detail
Sigma-Aldrich (56480)  N-Hydroxysuccinimide  purum, ≥97.0% (T) 6066-82-6 56480-25G 558.09CNY Detail
Sigma-Aldrich (56480)  N-Hydroxysuccinimide  purum, ≥97.0% (T) 6066-82-6 56480-100G 1,404.00CNY Detail
Sigma-Aldrich (56480)  N-Hydroxysuccinimide  purum, ≥97.0% (T) 6066-82-6 56480-1KG 11,103.30CNY Detail
Aldrich (130672)  N-Hydroxysuccinimide  98% 6066-82-6 130672-5G 180.18CNY Detail
Aldrich (130672)  N-Hydroxysuccinimide  98% 6066-82-6 130672-25G 304.20CNY Detail

6066-82-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name N-Hydroxysuccinimide

1.2 Other means of identification

Product number -
Other names 1-hydroxypyrrolidine-2,5-dione

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6066-82-6 SDS

6066-82-6Synthetic route

2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)acetate

2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)acetate

girard's reagent T
123-46-6

girard's reagent T

isobutylamine
78-81-9

isobutylamine

A

1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

B

diisopropyl (2-(isobutylamino)-2-oxoethyl)phosphonate
1426294-35-0

diisopropyl (2-(isobutylamino)-2-oxoethyl)phosphonate

C

C13H29N3O5P(1+)*Cl(1-)

C13H29N3O5P(1+)*Cl(1-)

Conditions
ConditionsYield
Stage #1: 2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)acetate; isobutylamine In dichloromethane at 20℃; for 4h;
Stage #2: girard's reagent T In methanol; dichloromethane
A n/a
B 99%
C n/a
2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)acetate

2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)acetate

girard's reagent T
123-46-6

girard's reagent T

6-amino-3,4-benzodioxane
22013-33-8

6-amino-3,4-benzodioxane

A

1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

B

diisopropyl (2-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)amino)-2-oxoethyl)phosphonate
1426294-37-2

diisopropyl (2-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)amino)-2-oxoethyl)phosphonate

C

C13H29N3O5P(1+)*Cl(1-)

C13H29N3O5P(1+)*Cl(1-)

Conditions
ConditionsYield
Stage #1: 2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)acetate; 6-amino-3,4-benzodioxane In dichloromethane at 20℃; for 4h;
Stage #2: girard's reagent T In methanol; dichloromethane
A n/a
B 99%
C n/a
2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)acetate

2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)acetate

girard's reagent T
123-46-6

girard's reagent T

4-methoxy-benzylamine
2393-23-9

4-methoxy-benzylamine

A

1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

B

diisopropyl (2-((4-methoxybenzyl)amino)-2-oxoethyl)phosphonate
1426294-38-3

diisopropyl (2-((4-methoxybenzyl)amino)-2-oxoethyl)phosphonate

C

C13H29N3O5P(1+)*Cl(1-)

C13H29N3O5P(1+)*Cl(1-)

Conditions
ConditionsYield
Stage #1: 2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)acetate; 4-methoxy-benzylamine In dichloromethane at 20℃; for 4h;
Stage #2: girard's reagent T In methanol; dichloromethane
A n/a
B 99%
C n/a
2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)propanoate
1426294-34-9

2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)propanoate

girard's reagent T
123-46-6

girard's reagent T

2-(3,4-dimethoxyphenyl)-ethylamine
120-20-7

2-(3,4-dimethoxyphenyl)-ethylamine

A

1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

B

diisopropyl (1-((3,4-dimethoxyphenethyl)amino)-1-oxopropan-2-yl)phosphonate
1426294-48-5

diisopropyl (1-((3,4-dimethoxyphenethyl)amino)-1-oxopropan-2-yl)phosphonate

C

C14H31N3O5P(1+)*Cl(1-)

C14H31N3O5P(1+)*Cl(1-)

Conditions
ConditionsYield
Stage #1: 2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)propanoate; 2-(3,4-dimethoxyphenyl)-ethylamine In dichloromethane at 20℃; for 4h;
Stage #2: girard's reagent T In methanol; dichloromethane
A n/a
B 99%
C n/a
2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)acetate

2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)acetate

girard's reagent T
123-46-6

girard's reagent T

phenethylamine
64-04-0

phenethylamine

A

1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

B

diisopropyl (2-oxo-2-(phenethylamino)ethyl)phosphonate
1426294-39-4

diisopropyl (2-oxo-2-(phenethylamino)ethyl)phosphonate

C

C13H29N3O5P(1+)*Cl(1-)

C13H29N3O5P(1+)*Cl(1-)

Conditions
ConditionsYield
Stage #1: 2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)acetate; phenethylamine In dichloromethane at 20℃; for 4h;
Stage #2: girard's reagent T In methanol; dichloromethane
A n/a
B 99%
C n/a
2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)acetate

2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)acetate

girard's reagent T
123-46-6

girard's reagent T

4-Methoxyphenethylamine
55-81-2

4-Methoxyphenethylamine

A

1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

B

diisopropyl (2-((4-methoxyphenethyl)amino)-2-oxoethyl)phosphonate
1426294-40-7

diisopropyl (2-((4-methoxyphenethyl)amino)-2-oxoethyl)phosphonate

C

C13H29N3O5P(1+)*Cl(1-)

C13H29N3O5P(1+)*Cl(1-)

Conditions
ConditionsYield
Stage #1: 2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)acetate; 4-Methoxyphenethylamine In dichloromethane at 20℃; for 4h;
Stage #2: girard's reagent T In methanol; dichloromethane
A n/a
B 99%
C n/a
4-azidobenzoic acid N-hydroxysuccinimide ester
53053-08-0

4-azidobenzoic acid N-hydroxysuccinimide ester

1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

Conditions
ConditionsYield
With chitosan In aq. phosphate buffer; dichloromethane at 50℃; for 5h; Solvent; Temperature; Microwave irradiation;98.2%
2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)acetate

2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)acetate

girard's reagent T
123-46-6

girard's reagent T

2-(3,4-dimethoxyphenyl)-ethylamine
120-20-7

2-(3,4-dimethoxyphenyl)-ethylamine

A

1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

B

diisopropyl (2-((3,4-dimethoxyphenethyl)amino)-2-oxoethyl)phosphonate
1426294-41-8

diisopropyl (2-((3,4-dimethoxyphenethyl)amino)-2-oxoethyl)phosphonate

C

C13H29N3O5P(1+)*Cl(1-)

C13H29N3O5P(1+)*Cl(1-)

Conditions
ConditionsYield
Stage #1: 2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)acetate; 2-(3,4-dimethoxyphenyl)-ethylamine In dichloromethane at 20℃; for 4h;
Stage #2: girard's reagent T In methanol; dichloromethane
A n/a
B 96%
C n/a
2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)propanoate
1426294-34-9

2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)propanoate

girard's reagent T
123-46-6

girard's reagent T

benzylamine
100-46-9

benzylamine

A

1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

B

diisopropyl (1-(benzylamino)-1-oxopropan-2-yl)phosphonate
1426294-46-3

diisopropyl (1-(benzylamino)-1-oxopropan-2-yl)phosphonate

C

C14H31N3O5P(1+)*Cl(1-)

C14H31N3O5P(1+)*Cl(1-)

Conditions
ConditionsYield
Stage #1: 2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)propanoate; benzylamine In dichloromethane at 20℃; for 4h;
Stage #2: girard's reagent T In methanol; dichloromethane
A n/a
B 95%
C n/a
succinic acid
110-15-6

succinic acid

1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

Conditions
ConditionsYield
With hydroxylamine hydrochloride; potassium carbonate; acetic acid In cyclohexane at 65℃; for 9h; Product distribution / selectivity;94.7%
With hydroxyammonium sulfate; boric acid; hypophosphorous acid; sodium hydroxide In toluene at 95℃; Temperature; Reflux;85.5%
With hydroxylamine; acetic acid In cyclohexane; water for 6 - 9h; Product distribution / selectivity; Heating / reflux;64.9%
2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)propanoate
1426294-34-9

2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)propanoate

girard's reagent T
123-46-6

girard's reagent T

phenethylamine
64-04-0

phenethylamine

A

1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

B

diisopropyl (1-oxo-1-(phenethylamino)propan-2-yl)phosphonate
1426294-47-4

diisopropyl (1-oxo-1-(phenethylamino)propan-2-yl)phosphonate

C

C14H31N3O5P(1+)*Cl(1-)

C14H31N3O5P(1+)*Cl(1-)

Conditions
ConditionsYield
Stage #1: 2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)propanoate; phenethylamine In dichloromethane at 20℃; for 4h;
Stage #2: girard's reagent T In methanol; dichloromethane
A n/a
B 94%
C n/a
N-(tert-butoxycarbonyl)-succinimide
41839-96-7

N-(tert-butoxycarbonyl)-succinimide

1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

Conditions
ConditionsYield
With hydroxylamine In acetonitrile at 20℃;93%
benzoic acid N-hydroxysuccinimide ester
23405-15-4

benzoic acid N-hydroxysuccinimide ester

Trimethylenediamine
109-76-2

Trimethylenediamine

A

1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

B

N,N'-(propane-1,3-diyl)dibenzamide
68388-03-4

N,N'-(propane-1,3-diyl)dibenzamide

Conditions
ConditionsYield
In methanol at 25℃; for 0.166667h;A n/a
B 92%
2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)acetate

2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)acetate

girard's reagent T
123-46-6

girard's reagent T

p-toluidine
106-49-0

p-toluidine

A

1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

B

C13H29N3O5P(1+)*Cl(1-)

C13H29N3O5P(1+)*Cl(1-)

C

diisopropyl (2-oxo-2-(p-tolylamino)ethyl)phosphonate
16634-86-9

diisopropyl (2-oxo-2-(p-tolylamino)ethyl)phosphonate

Conditions
ConditionsYield
Stage #1: 2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)acetate; p-toluidine In dichloromethane at 20℃; for 4h;
Stage #2: girard's reagent T In methanol; dichloromethane
A n/a
B n/a
C 92%
succinic acid anhydride
108-30-5

succinic acid anhydride

1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

Conditions
ConditionsYield
With hydroxylamine hydrochloride; sodium hydroxide In water at 0 - 25℃; for 0.5h; Large scale;90%
With hydroxylamine hydrochloride; sodium methylate a) methanol, 60 deg C, 1.5 h, b) xylene, reflux, 4 h;41%
With pyridine; hydroxylamine hydrochloride for 4h; Heating; Inert atmosphere;
With hydroxylamine at 160℃;
With sulfuric acid; hydroxylamine hydrochloride In water at 100 - 160℃; Reagent/catalyst;
tyrosamine
51-67-2

tyrosamine

2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)acetate

2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)acetate

girard's reagent T
123-46-6

girard's reagent T

A

1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

B

diisopropyl (2-((4-hydroxyphenethyl)amino)-2-oxoethyl)phosphonate
1426294-42-9

diisopropyl (2-((4-hydroxyphenethyl)amino)-2-oxoethyl)phosphonate

C

C13H29N3O5P(1+)*Cl(1-)

C13H29N3O5P(1+)*Cl(1-)

Conditions
ConditionsYield
Stage #1: tyrosamine; 2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)acetate In dichloromethane at 20℃; for 4h;
Stage #2: girard's reagent T In methanol; dichloromethane
A n/a
B 89%
C n/a
2-Methylbutylamine
96-15-1

2-Methylbutylamine

2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)acetate

2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)acetate

girard's reagent T
123-46-6

girard's reagent T

A

1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

B

diisopropyl (2-((2-methylbutyl)amino)-2-oxoethyl)phosphonate
1426294-36-1

diisopropyl (2-((2-methylbutyl)amino)-2-oxoethyl)phosphonate

C

C13H29N3O5P(1+)*Cl(1-)

C13H29N3O5P(1+)*Cl(1-)

Conditions
ConditionsYield
Stage #1: 2-Methylbutylamine; 2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)acetate In dichloromethane at 20℃; for 4h;
Stage #2: girard's reagent T In methanol; dichloromethane
A n/a
B 87%
C n/a
pyrrolidine
123-75-1

pyrrolidine

2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)propanoate
1426294-34-9

2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)propanoate

girard's reagent T
123-46-6

girard's reagent T

A

1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

B

diisopropyl (1-oxo-1-(pyrrolidin-1-yl)propan-2-yl)phosphonate
1426294-44-1

diisopropyl (1-oxo-1-(pyrrolidin-1-yl)propan-2-yl)phosphonate

C

C14H31N3O5P(1+)*Cl(1-)

C14H31N3O5P(1+)*Cl(1-)

Conditions
ConditionsYield
Stage #1: pyrrolidine; 2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)propanoate In dichloromethane at 20℃; for 4h;
Stage #2: girard's reagent T In methanol; dichloromethane
A n/a
B 86%
C n/a
2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)propanoate
1426294-34-9

2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)propanoate

girard's reagent T
123-46-6

girard's reagent T

isobutylamine
78-81-9

isobutylamine

A

1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

B

diisopropyl (1-(isobutylamino)-1-oxopropan-2-yl)phosphonate
1426294-43-0

diisopropyl (1-(isobutylamino)-1-oxopropan-2-yl)phosphonate

C

C14H31N3O5P(1+)*Cl(1-)

C14H31N3O5P(1+)*Cl(1-)

Conditions
ConditionsYield
Stage #1: 2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)propanoate; isobutylamine In dichloromethane at 20℃; for 4h;
Stage #2: girard's reagent T In methanol; dichloromethane
A n/a
B 83%
C n/a
N-Bromosuccinimide
128-08-5

N-Bromosuccinimide

1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

Conditions
ConditionsYield
With water In ethanol at 20℃; for 2h;82%
2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)acetate

2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)acetate

girard's reagent T
123-46-6

girard's reagent T

benzylamine
100-46-9

benzylamine

A

1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

B

C13H29N3O5P(1+)*Cl(1-)

C13H29N3O5P(1+)*Cl(1-)

C

diisopropyl (2-(benzylamino)-2-oxoethyl)phosphonate
113368-98-2

diisopropyl (2-(benzylamino)-2-oxoethyl)phosphonate

Conditions
ConditionsYield
Stage #1: 2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)acetate; benzylamine In dichloromethane at 20℃; for 4h;
Stage #2: girard's reagent T In methanol; dichloromethane
A n/a
B n/a
C 81%
di(succinimido) carbonate
74124-79-1

di(succinimido) carbonate

α-methyl-ω-(1-(4-hydroxymethyl-2,6-dimethylphenoxy)-acet-2-oxy)poly(ethylene glycol)

α-methyl-ω-(1-(4-hydroxymethyl-2,6-dimethylphenoxy)-acet-2-oxy)poly(ethylene glycol)

A

1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

B

α-methyl-ω-(1-(4-(N-succinimidyloxycarbonyloxymethyl)-2,6-dimethylphenoxy)-acet-2-oxy)poly(ethylene glycol)

α-methyl-ω-(1-(4-(N-succinimidyloxycarbonyloxymethyl)-2,6-dimethylphenoxy)-acet-2-oxy)poly(ethylene glycol)

Conditions
ConditionsYield
With pyridine In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃; for 20h;A n/a
B 79%
benzoic acid N-hydroxysuccinimide ester
23405-15-4

benzoic acid N-hydroxysuccinimide ester

Trimethylenediamine
109-76-2

Trimethylenediamine

A

1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

B

N-(3-aminopropyl)benzamide
6108-74-3

N-(3-aminopropyl)benzamide

C

N,N'-(propane-1,3-diyl)dibenzamide
68388-03-4

N,N'-(propane-1,3-diyl)dibenzamide

Conditions
ConditionsYield
In methanol at 25℃; for 2h;A n/a
B 20%
C 77%
In methanol at 25℃; for 0.116667h;A n/a
B 63%
C 31%
2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)propanoate
1426294-34-9

2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)propanoate

girard's reagent T
123-46-6

girard's reagent T

6-amino-3,4-benzodioxane
22013-33-8

6-amino-3,4-benzodioxane

A

1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

B

diisopropyl (1-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)amino)-1-oxopropan-2-yl)phosphonate
1426294-45-2

diisopropyl (1-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)amino)-1-oxopropan-2-yl)phosphonate

C

C14H31N3O5P(1+)*Cl(1-)

C14H31N3O5P(1+)*Cl(1-)

Conditions
ConditionsYield
Stage #1: 2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)propanoate; 6-amino-3,4-benzodioxane In dichloromethane at 20℃; for 4h;
Stage #2: girard's reagent T In methanol; dichloromethane
A n/a
B 73%
C n/a
estradiol
50-28-2

estradiol

N-Hydroxysulfosuccinimide sodium salt

N-Hydroxysulfosuccinimide sodium salt

A

1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

B

estradiol-3-sulfate
481-96-9

estradiol-3-sulfate

Conditions
ConditionsYield
With AST In acetone Enzymatic reaction;A n/a
B 68%
pyrrolidine
123-75-1

pyrrolidine

2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)acetate

2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)acetate

girard's reagent T
123-46-6

girard's reagent T

A

1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

B

C13H29N3O5P(1+)*Cl(1-)

C13H29N3O5P(1+)*Cl(1-)

C

diisopropyl (2-oxo-2-(pyrrolidin-1-yl)ethyl)phosphonate
66932-77-2

diisopropyl (2-oxo-2-(pyrrolidin-1-yl)ethyl)phosphonate

Conditions
ConditionsYield
Stage #1: pyrrolidine; 2,5-dioxopyrrolidin-1-yl 2-(diisopropoxyphosphoryl)acetate In dichloromethane at 20℃; for 4h;
Stage #2: girard's reagent T In methanol; dichloromethane
A n/a
B n/a
C 59%
hydroxylamine succinic acid salt
869669-06-7

hydroxylamine succinic acid salt

acetic acid
64-19-7

acetic acid

A

1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

B

acetylhydroxamic acid
546-88-3

acetylhydroxamic acid

Conditions
ConditionsYield
for 10 - 15h; Product distribution / selectivity; Heating / reflux;A 54.4%
B 3.7%
N-acetoxysuccinimide
14464-29-0

N-acetoxysuccinimide

menthyl alcohol

menthyl alcohol

A

1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

acetic acid mentyl ester

acetic acid mentyl ester

Conditions
ConditionsYield
With tetrabutylammonium tricarbonylnitrosylferrate In hexane at 20 - 80℃; Molecular sieve; Inert atmosphere;A n/a
B 5%
N-hydroxysuccinimide
4743-99-1

N-hydroxysuccinimide

1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

Conditions
ConditionsYield
beim Aufbewahren ueber Schwefelsaeure;
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

acetic anhydride
108-24-7

acetic anhydride

N-acetoxysuccinimide
14464-29-0

N-acetoxysuccinimide

Conditions
ConditionsYield
for 15h;100%
With triethylamine for 0.5h;90%
With hydrogenchloride for 0.25h; Heating;79.9%
nicotinic acid
59-67-6

nicotinic acid

1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

nicotinic acid succinimidyl ester
78348-28-4

nicotinic acid succinimidyl ester

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In 1,4-dioxane100%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran at 20℃; for 48h;85%
With dicyclohexyl-carbodiimide In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃;80%
lauric acid
143-07-7

lauric acid

1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

N-succinimidyl laurate
14565-47-0

N-succinimidyl laurate

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In dichloromethane for 24h;100%
With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dichloromethane for 3h;98%
With dicyclohexyl-carbodiimide In ethyl acetate for 6h;98%
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

heptanedioic acid
111-16-0

heptanedioic acid

1-({7-[(2,5-dioxo-1-pyrrolidinyl)oxy]-7-oxoheptanoyl}-oxy)-2,5-pyrrolidine-dione
74648-14-9

1-({7-[(2,5-dioxo-1-pyrrolidinyl)oxy]-7-oxoheptanoyl}-oxy)-2,5-pyrrolidine-dione

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃; for 18h;100%
With dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃; for 18h;71%
With dicyclohexyl-carbodiimide
With dicyclohexyl-carbodiimide In tetrahydrofuran for 6h;
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

t-Boc-L-valine
13734-41-3

t-Boc-L-valine

Boc-Val-ONSu
3392-12-9

Boc-Val-ONSu

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 72h; Inert atmosphere; Sealed tube;100%
In tetrahydrofuran at 0 - 20℃; for 16h;72%
With dicyclohexyl-carbodiimide In 1,2-dimethoxyethane at 5℃; for 6h;69.5%
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

N-tert-butoxycarbonyl-L-leucine
13139-15-6

N-tert-butoxycarbonyl-L-leucine

Boc-Leu-ONSu
3392-09-4

Boc-Leu-ONSu

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In dichloromethane at 0 - 4℃;100%
With dicyclohexyl-carbodiimide In 1,4-dioxane Ambient temperature;93%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran; dichloromethane at 20℃; for 18h;93%
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

N-tert-butoxycarbonyl-L-methionine
2488-15-5

N-tert-butoxycarbonyl-L-methionine

tertbutoxycarbonyl-L-methionine N-hydroxysuccinimide ester
3845-64-5

tertbutoxycarbonyl-L-methionine N-hydroxysuccinimide ester

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In tetrahydrofuran at 0℃; for 18h;100%
With N-ethylmorpholine;; benzotriazol-1-ol In dichloromethane 1) 0 deg C, 2 h, 2) overnight, r.t.;66%
With dicyclohexyl-carbodiimide In ethyl acetate a.) 0 deg C, 2 h, b.) r.t., 18 h;
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

4-iodobenzoic acid
619-58-9

4-iodobenzoic acid

2,5-dioxopyrrolidin-1-yl 4-iodobenzoate
39028-25-6

2,5-dioxopyrrolidin-1-yl 4-iodobenzoate

Conditions
ConditionsYield
With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dichloromethane for 2h; Heating;100%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 2h; Inert atmosphere;100%
With dicyclohexyl-carbodiimide In 1,4-dioxane at 24.85℃; for 24h;99%
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

CbzGlyGly
2566-19-0

CbzGlyGly

Cbz-Gly-Gly-OSucc
32943-08-1

Cbz-Gly-Gly-OSucc

Conditions
ConditionsYield
With benzotriazol-1-ol In dichloromethane Condensation;100%
With dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 4℃;
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

Boc-Lys(Z)-OH
2389-45-9

Boc-Lys(Z)-OH

Boc-Lys(Z)-OSu
34404-36-9

Boc-Lys(Z)-OSu

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide 1.) EtOAc, 25 deg C, 3 h, 2.) Et2O, overnight;100%
With dicyclohexyl-carbodiimide In tetrahydrofuran; N,N-dimethyl-formamide for 20h; Ambient temperature;
With diisopropyl-carbodiimide at 0 - 20℃; for 25h;
With dicyclohexyl-carbodiimide In tetrahydrofuran at 0 - 20℃; for 8h;
With dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 20℃; Inert atmosphere;
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

4-azidobenzoic acid
6427-66-3

4-azidobenzoic acid

4-azidobenzoic acid N-hydroxysuccinimide ester
53053-08-0

4-azidobenzoic acid N-hydroxysuccinimide ester

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 23℃; for 21h; Inert atmosphere; Darkness;100%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 16h; Inert atmosphere; Darkness;97%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 16h; Inert atmosphere; Darkness;97%
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

N-(tert-butoxycarbonyl)sarcosine
13734-36-6

N-(tert-butoxycarbonyl)sarcosine

tert-butyl N-{2-[(2,5-dioxopyrrolidin-1-yl)oxy]-2-hydroxyethyl}-N-methylcarbamate
80621-90-5

tert-butyl N-{2-[(2,5-dioxopyrrolidin-1-yl)oxy]-2-hydroxyethyl}-N-methylcarbamate

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 20h;100%
With dicyclohexyl-carbodiimide In 1,2-dimethoxyethane at 0℃; for 0.5h;88%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide63%
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

BOC-L-aspartic acid 4-benzyl ester
7536-58-5

BOC-L-aspartic acid 4-benzyl ester

Nα-t-butoxycarbonylaspartic acid α-N-hydroxysuccinimide ester β-benzyl ester
13798-75-9

Nα-t-butoxycarbonylaspartic acid α-N-hydroxysuccinimide ester β-benzyl ester

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In tetrahydrofuran at 0℃; for 18h;100%
With dicyclohexyl-carbodiimide In ethyl acetate at -5 - 4℃; for 5h;90%
With dicyclohexyl-carbodiimide In 1,4-dioxane73%
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

3-(tritylthio) propanoic acid
27144-18-9

3-(tritylthio) propanoic acid

3-(triphenylmethylthio)propionic acid N-hydroxysuccinimide ester
129431-12-5

3-(triphenylmethylthio)propionic acid N-hydroxysuccinimide ester

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In 1,4-dioxane; ethyl acetate at 20℃;100%
With dicyclohexyl-carbodiimide In tetrahydrofuran at 0 - 20℃; for 4h; Inert atmosphere;71%
With dicyclohexyl-carbodiimide In tetrahydrofuran at 0 - 20℃; for 4h; Inert atmosphere;71%
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

Fmoc-Val-OH
68858-20-8

Fmoc-Val-OH

2,5-dioxopyrrolidin-1-yl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valinate
130878-68-1

2,5-dioxopyrrolidin-1-yl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valinate

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃; for 9h;100%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran; dichloromethane at 0 - 25℃;96%
With dicyclohexyl-carbodiimide In tetrahydrofuran at 0 - 20℃;96%
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

Boc-D-Phg-OH
33125-05-2

Boc-D-Phg-OH

N-(tert-butoxycarbonyl)-D-phenylglycine N-succinimido ester
39249-27-9

N-(tert-butoxycarbonyl)-D-phenylglycine N-succinimido ester

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In 1,4-dioxane100%
With dicyclohexyl-carbodiimide In tetrahydrofuran for 43h;98%
With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In N,N-dimethyl-formamide for 18h;
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

α-N-carbobenzoxy-δ-acetoxy-D-norvaline
125050-13-7

α-N-carbobenzoxy-δ-acetoxy-D-norvaline

5-Acetoxy-2-benzyloxycarbonylamino-pentanoic acid 2,5-dioxo-pyrrolidin-1-yl ester
125076-27-9

5-Acetoxy-2-benzyloxycarbonylamino-pentanoic acid 2,5-dioxo-pyrrolidin-1-yl ester

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide100%
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

(N5-acetyl-N5-(benzyloxy)-N2-(benzyloxycarbonyl)-L-ornithyl)-(N5-acetyl-N5-(benzyloxy)-L-ornithyl)-N5-acetyl-N5-(benzyloxy)-L-ornithine
124620-56-0

(N5-acetyl-N5-(benzyloxy)-N2-(benzyloxycarbonyl)-L-ornithyl)-(N5-acetyl-N5-(benzyloxy)-L-ornithyl)-N5-acetyl-N5-(benzyloxy)-L-ornithine

N5-acetyl-N5-(benzyloxy)-N2-(benzyloxycarbonyl)-L-ornithyl-N5-acetyl-N5-(benzyloxy)-L-ornithyl-N5-acetyl-N5-(benzyloxy)-L-ornithine succinimido ester
131080-79-0

N5-acetyl-N5-(benzyloxy)-N2-(benzyloxycarbonyl)-L-ornithyl-N5-acetyl-N5-(benzyloxy)-L-ornithyl-N5-acetyl-N5-(benzyloxy)-L-ornithine succinimido ester

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In tetrahydrofuran Ambient temperature;100%
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

N-tert-butoxycarbonyl glutamic acid tert-butyl ester
24277-39-2

N-tert-butoxycarbonyl glutamic acid tert-butyl ester

N-α-tert-butoxycarbonyl-L-glutamic acid γ-N-succinimidyl ester α-tert-butyl ester
81659-82-7

N-α-tert-butoxycarbonyl-L-glutamic acid γ-N-succinimidyl ester α-tert-butyl ester

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In diethyl ether at 20℃; for 24h; Temperature; Time;100%
With dicyclohexyl-carbodiimide; dimethylethylbenzylamine In diethyl ether at 22℃; for 48h;90%
With dicyclohexyl-carbodiimide In diethyl ether at 22℃; for 48h;90%
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

Cbz-ΔGlu-OMe
130680-59-0

Cbz-ΔGlu-OMe

(Z)-Cbz-ΔGlu(OSu)-OMe
130680-61-4

(Z)-Cbz-ΔGlu(OSu)-OMe

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In tetrahydrofuran100%
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

4-(4′-methyl-[2,2′-bipyridin]-4-yl)butanoic acid
114527-28-5

4-(4′-methyl-[2,2′-bipyridin]-4-yl)butanoic acid

4-<3-carbonyl-3-(succinimidyl)propyl>-4'-methyl-2,2'-bipyridine
130699-88-6

4-<3-carbonyl-3-(succinimidyl)propyl>-4'-methyl-2,2'-bipyridine

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 2h;100%
With dicyclohexyl-carbodiimide In ethyl acetate for 12h; Ambient temperature;59%
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

(1R,3R,4S)-8-phenyl-p-menthan-3-yl hydrogen isopropylmalonate
111042-78-5, 111042-79-6

(1R,3R,4S)-8-phenyl-p-menthan-3-yl hydrogen isopropylmalonate

2-Isopropyl-malonic acid 2,5-dioxo-pyrrolidin-1-yl ester (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

2-Isopropyl-malonic acid 2,5-dioxo-pyrrolidin-1-yl ester (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane for 15h; Ambient temperature;100%
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

N-{3-[(tert-butoxycarbonyl)amino]propanoyl}-N-hydroxy-β-alanine
136413-25-7

N-{3-[(tert-butoxycarbonyl)amino]propanoyl}-N-hydroxy-β-alanine

3-[Benzyloxy-(3-tert-butoxycarbonylamino-propionyl)-amino]-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester
136413-26-8

3-[Benzyloxy-(3-tert-butoxycarbonylamino-propionyl)-amino]-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride Ambient temperature;100%
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

acetic acid
64-19-7

acetic acid

N-acetoxysuccinimide
14464-29-0

N-acetoxysuccinimide

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 16h; Inert atmosphere;100%
With dicyclohexyl-carbodiimide In 1,4-dioxane at 5 - 20℃; for 20h;93%
With dmap In dichloromethane for 1h; Ambient temperature;86%
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

bromoacetic acid
79-08-3

bromoacetic acid

bromoacetic acid N-hydroxusuccinimidyl ester
42014-51-7

bromoacetic acid N-hydroxusuccinimidyl ester

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In 1,4-dioxane at 20℃; for 2h;100%
With dicyclohexyl-carbodiimide In tetrahydrofuran at 5℃; for 144h;97%
With dicyclohexyl-carbodiimide In 1,4-dioxane for 1h; Ambient temperature;96%
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

n-tetradecanoic acid
544-63-8

n-tetradecanoic acid

N-succinimidyl myristate
69888-86-4

N-succinimidyl myristate

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In acetonitrile for 1.5h;100%
With dicyclohexyl-carbodiimide In ethyl acetate for 6h;98%
With dicyclohexyl-carbodiimide In ethyl acetate Ambient temperature;88%
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

Benzyl 6α-(methylthio)-6β-(phenoxyacetamido)penicillanate
55367-05-0

Benzyl 6α-(methylthio)-6β-(phenoxyacetamido)penicillanate

Benzyl 6α-(succinimido-oxy)-6β-(phenoxyacetamido)penicillanate
104702-12-7

Benzyl 6α-(succinimido-oxy)-6β-(phenoxyacetamido)penicillanate

Conditions
ConditionsYield
silver(I) acetate In N,N-dimethyl-formamide for 1h;100%
silver(I) acetate In N,N-dimethyl-formamide for 1.5h; -40 deg C to rt;100%
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

Boc-(Asn-Val-Orn(Z)-Leu-Pro)2-OH

Boc-(Asn-Val-Orn(Z)-Leu-Pro)2-OH

Boc-(Asn-Val-Orn(Z)-Leu-Pro)2-ONSu

Boc-(Asn-Val-Orn(Z)-Leu-Pro)2-ONSu

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; N,N-dimethyl-formamide at 0℃;100%
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

benzoic acid
65-85-0

benzoic acid

benzoic acid N-hydroxysuccinimide ester
23405-15-4

benzoic acid N-hydroxysuccinimide ester

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 16h; Inert atmosphere;100%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 0.166667h;97%
With 3-(5-nitro-2-oxo-1,2-dihydro-1-pyridyl)-1,2-benzisothiazole 1,1,-dioxide; triethylamine In dichloromethane -10 deg C -> r.t., overnight;93%
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

salicylic acid
69-72-7

salicylic acid

salicylic acid succinimidyl ester
70120-40-0

salicylic acid succinimidyl ester

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In 1,4-dioxane100%
With dicyclohexyl-carbodiimide In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃;95%
With dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃; for 12h;91%
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