170302-87-1

Basic information

• Product Name: 3-Piperidinemethanol, 1-acetyl- (9CI)
• Synonyms: 3-Piperidinemethanol, 1-acetyl- (9CI)
• CAS NO: 170302-87-1
• Molecular Formula: C8H15NO2
• Molecular Weight: 157.2102
• Product Categories: ACETYLGROUP
• Mol File: 170302-87-1.mol

Chemical Properties

• Boiling Point: 309.8±15.0 °C(Predicted)
• Appearance: /
• Density: 1.067±0.06 g/cm3(Predicted)
• PKA: 14.93±0.10(Predicted)
• CAS DataBase Reference: 3-Piperidinemethanol, 1-acetyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Piperidinemethanol, 1-acetyl- (9CI)(170302-87-1)
• EPA Substance Registry System: 3-Piperidinemethanol, 1-acetyl- (9CI)(170302-87-1)

Safety Data

• Hazardous Substances Data: 170302-87-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Piperidinemethanol, 1-acetyl(9CI) is used as a synthetic intermediate for the development of pharmaceuticals. Its presence of a piperidine ring, a common structural motif in many biologically active compounds, makes it a valuable component in the creation of new drugs.
Used in Research and Development:
In the field of medicinal chemistry, 3-Piperidinemethanol, 1-acetyl(9CI) is utilized as a research compound to explore its biological activity and understand its potential applications in therapeutics. Further research may reveal its full potential and contribute to the advancement of pharmaceutical formulations.
Used in Organic Synthesis:
3-Piperidinemethanol, 1-acetyl(9CI) is employed as a versatile building block in organic synthesis, particularly for the preparation of complex organic molecules and compounds with potential applications in various industries, including but not limited to pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 4606-65-9 3-(hydroxymethy)piperidine 
• 108-22-5 Isopropenyl acetate 

Downstream Products

• 181999-39-3 1-ethyl-3-methylenepiperidine 
• 181999-35-9 3-Methylene-1-(2-phenylselanyl-ethyl)-piperidine 
• 181999-37-1 1-(3-Iodomethyl-piperidin-1-yl)-ethanone 
• 181999-40-6 1-aza-5-methylbicyclo[3.2.1]octane 

Relevant articles and documents

Synthesis of nitrogen bridgehead bicyclic heterocycles via ring-closure of β-ammonio 5-hexenyl radicals

The 2-(3-methylenepiperidinyl)ethyl radical (6) displays considerable reluctance to ring-closure under conditions which its carbocyclic analog, the 2-(3-methylenecyclohexyl)ethyl radical (2), cyclizes essentially completely. Molecular mechanics calculations suggest that the increased activation barrier associated with ring-closure of 6 is the result of a higher than expected transition state energy. A study of the behavior of β-ammonio-substituted 5-hexenyl radicals, such as the 3,3-dimethyl-3-azonia-5-hexenyl radical (22), reveals that cyclization occurs readily. Treatment of 1-methyl-1-(2-(phenylselenyl)ethyl)-3-methylenepiperidinium iodide (20) with tributyltin hydride in tert-amyl alcohol yields the bridgehead nitrogen bicyclic heterocycle, 1,5-dimethyl-1-azoniabicyclo-[3.2.1]octane iodide (26), in excellent yield and without contamination, thus providing an attractive synthetic route to this hitherto unknown heterocyclic system.

ENZYME-MEDIATED ENANTIOSELECTIVE ACYLATION OF SECONDARY AMINES IN ORGANIC SOLVENTS

Porcine pancreatic lipase (PPL) and lipase Amano P catalyze the enantioselective acylation of cyclic 1,2- and 1,3-amino alcohol derivatives in organic solvents.The enantiomeric excesses (ee's) were shown to depend on the enzyme, reaction time, temperature and type of substrate.