4606-65-9

Basic information

• Product Name: 3-Piperidinemethanol
• Synonyms: RARECHEM AM LA 0073;3-Piperidinyl carbinol;piperidin-3-ylmethanol;3-Piperidine-methanol(3-(Hydroxymethyl)-piperidine) ;3-Piperidinemethanol,96%;1-ethoxycarbonyl;3-PIPERIDINE-METHANOL,98.0+%;1-piperidinecarboxylic acid, 3-(hydroxymethyl)-, 1,1-dimet
• CAS NO: 4606-65-9
• Molecular Formula: C₆H₁₃NO
• Molecular Weight: 115.17352
• EINECS: 225-013-0
• Product Categories: Alcohols and Derivatives;pharmacetical;Piperidine;Alkohols;Heterocyclic Compounds;Building Blocks;C5 to C7;Chemical Synthesis;Heterocyclic Building Blocks;Piperidines
• Mol File: 4606-65-9.mol
• Article Data: 20

Chemical Properties

• Melting Point: 106-107°C
• Boiling Point: 106-107 °C3.5 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: Clear/Liquid
• Density: 1.026 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00664mmHg at 25°C
• Refractive Index: 1.4940
• Storage Temp.: Room temperature.
• Solubility: Chloroform (Slightly), DMSO (Slightly, Sonicated), Methanol (Slightly)
• PKA: 14.93±0.10(Predicted)
• Sensitive: Hygroscopic
• BRN: 103058
• CAS DataBase Reference: 3-Piperidinemethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Piperidinemethanol(4606-65-9)
• EPA Substance Registry System: 3-Piperidinemethanol(4606-65-9)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3263 8/PG 2
• WGK Germany: 2
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 4606-65-9(Hazardous Substances Data)

Usage

Chemical Properties

White solid

Uses

Different sources of media describe the Uses of 4606-65-9 differently. You can refer to the following data:
1. Reactant for synthesis of: CB2 receptor agonists for the treatment of chronic pain1 Spiroimidazolidinone NPC1L1 inhibitors2 Quorum sensing modulators3 Protein lysine methyltransferase G9a inhibitors4 P2Y12 antagonists for inhibition of platelet aggregation5 Soluble epoxide hydrolase inhibitors6
2. Reactant for synthesis of: CB2 receptor agonists for the treatment of chronic pain Spiroimidazolidinone NPC1L1 inhibitors Quorum sensing modulators Protein lysine methyltransferase G9a inhibitors P2Y12 antagonists for inhibition of platelet aggregation Soluble epoxide hydrolase inhibitors

General Description

The standard molar energy of combustion of 3-Piperidinemethanol has been studied.

InChI:InChI=1/C6H13NO/c8-5-6-2-1-3-7-4-6/h6-8H,1-5H2/p+1/t6-/m0/s1

Upstream product

• 71962-74-8 Ethyl nipecotate 
• 37675-18-6 (S)-(+)-nipecotic acid ethyl ester 
• 140645-20-1 t-butyl (R,S)-3-<(butyryloxy)methyl>-1-piperidine-carboxylate 
• 175694-36-7 (3R,5S)-Piperidine-1,3,5-tricarboxylic acid 1-benzyl ester 3-methyl ester 
• 88466-73-3 Z-β²hPro-OMe 
• 1221818-73-0 (3S,5R)-Piperidine-1,3,5-tricarboxylic acid benzyl ester dimethyl ester 
• 405061-52-1 N-Cbz-3-hydroxymethylpiperidine 
• 140695-84-7 tert-butyl (3S)-3-(hydroxymethyl)piperidine-1-carboxylate 
• 383865-57-4 4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl-amine 
• 131080-21-2 (1-Allyl-[3]piperidyl)-methanol 
• 3367-95-1 N,N-diethylpiperidine-3-carboxamide 
• 614-18-6 3-pyridinecarboxylic acid ethyl ester 
• 851956-01-9 (S)-(+)-3-piperidinecarboxylic acid hydrochloride 
• 5621-43-2 diethyl 2-methyleneglutarate 

Downstream Products

• 415722-06-4 [1-(4-methylbenzyl)-3-piperidinyl]methanol 
• 116574-71-1 (±)-tert-butyl 3-(hydroxymethyl)piperidine-1-carboxylate 
• 205242-48-4 (1-Trityl-piperidin-3-yl)-methanol 
• 214548-40-0 (+/-)-ethyl 3-(hydroxymethyl)-1-piperidinecarboxylate 
• 327188-64-7 4-(4-chlorophenyl)-2-(3-hydroxymethyl-1-piperidinyl)-5-[3-(2-methoxyphenoxy)propyl]oxazole 
• 876147-80-7 2-[3-(hydroxymethyl)piperidine-1-yl]benzaldehyde 
• 207730-18-5 (N->B)-diphenyl(3-piperidylmethoxy)borane 
• 1260000-99-4 C₃₂H₄₂N₄O₄ 
• 1265322-29-9 2-(3-(hydroxymethyl)piperidin-1-yl)-1-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethanol 
• 1341126-88-2 benzyl 3-{[(2-aminoethyl)amino]methyl}piperidine-1-carboxylate 

Relevant articles and documents

Manganese Catalyzed Hydrogenation of Enantiomerically Pure Esters

A manganese-catalyzed hydrogenation of esters has been accomplished with TONs up to 1000, using cheap, environmentally benign, potassium carbonate and simple alcohols as activator and solvent, respectively. The weakly basic conditions lead to good functional group tolerance and enable the hydrogenation of enantiomerically enriched α-chiral esters with essentially no loss of stereochemical integrity.

PROCESS FOR PREPARING ENANTIOMERICALLY ENRICHED 3-HYDROXYMETHYLPIPERIDINE

The present invention relates to a process for preparing enantiomerically enriched 3-hydroxymethylpiperidine and in particular of the S-enantiomer of (S)-3-hydroxymethyl- piperidine in high chemical and optical purity. The invention also relates to extremely pure (S)-3-hydroxymethylpiperidine and (R)-3-hydroxymethylpiperidine.

FARNESYL PROTEIN TRANSFERASE INHIBITORS

Disclosed are compounds of formula (1.0), wherein R represents a cyclic moiety to which is bound an imodazolylalkyl group; R represents a carbamate, urea, amide or sulfonamide group; and the remaining substituents are as defined herein. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.