- An Efficient Synthesis of Radicinin Analogues
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We described herein an enantio- and diastereoselective total synthesis of two radicinin analogues 13 and 14. 13 has been subjected to biological tests, exhibiting the lowest toxicity of all radicinin analogues that have been investigated to date and it de
- Eh, Marcus,Schomburg, Dietmar,Schicht, Kathrin,Kalesse, Markus
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- Synthesis of angiolam A
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The first total synthesis of angiolam A has been accomplished in 18 steps. Key steps include vinylogous Mukaiyama aldol reactions of aldehydederived dienol ethers, conjugate reduction of the resulting double bond followed by diastereoselective protonation
- Gieseler, Marc Timo,Kalesse, Markus
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supporting information
p. 548 - 551
(2014/04/03)
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- Asymmetric synthesis of (+)-chloriolide
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An asymmetric synthesis of 12-membered ring macrolide, chloriolide has been accomplished by adopting a linear strategy. Lipase-catalyzed enzymatic kinetic resolution (EKR), asymmetric alkynylation using Trost pro-phenol catalyst followed by Yamaguchi macr
- Das, Tapas,Jana, Nandan,Nanda, Samik
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scheme or table
p. 2644 - 2647
(2010/06/16)
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- Natural product-guided synthesis of a spiroacetal collection reveals modulators of tubulin cytoskeleton integrity
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The spiro[5.5]ketal moiety forms the underlying structural skeleton of numerous biologically active natural products. Since simplified but characteristic spiroketals derived from the parent natural products retain biological activity, the spiro[5.5]ketal
- Barun, Okram,Kumar, Kamal,Sommer, Stefan,Langerak, Anette,Mayer, Thomas U.,Mueller, Oliver,Waldmann, Herbert
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p. 4773 - 4788
(2007/10/03)
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- MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS
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The present invention provides compounds having formula (I), and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1 -R11, t, X, Y, Z, and n are as defined herein.
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Page/Page column 100-101
(2010/02/07)
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