170649-27-1

Upstream product

• 24621-61-2 1,3-butanediol 
• 2186-92-7 p-Anisaldehyde dimethyl acetal 
• 1228300-89-7 C₁₈H₃₂O₃Si 
• 350848-03-2 methyl (S)-3-(4-methoxybenzyloxy)butanoate 
• 170649-26-0 (S)-3-(4-Methoxy-benzyloxy)-butyric acid ethyl ester 

Downstream Products

• 1513700-69-0 C₁₂H₁₇IO₂ 
• 1513700-71-4 C₃₄H₆₄O₄S₂Si₂ 
• 195392-68-8 (4RS,3'S)-4-formyloxy-1-[3'-(4-methoxybenzyloxy)butan-1'-yl]azetidin-2-one 
• 195392-63-3 (4RS,3'S)-1-[3'-(4-methoxybenzyloxy)butan-1'-yl]-4-vinyloxyazetidin-2-one 
• 1026861-89-1 Trifluoro-methanesulfonic acid (S)-3-(4-methoxy-benzyloxy)-butyl ester 
• 170649-28-2 (3S)-3-<(p-methoxybenzyl)-oxy>-butanal 

Relevant academic research and scientific papers

An Efficient Synthesis of Radicinin Analogues

We described herein an enantio- and diastereoselective total synthesis of two radicinin analogues 13 and 14. 13 has been subjected to biological tests, exhibiting the lowest toxicity of all radicinin analogues that have been investigated to date and it de

Synthesis of angiolam A

The first total synthesis of angiolam A has been accomplished in 18 steps. Key steps include vinylogous Mukaiyama aldol reactions of aldehydederived dienol ethers, conjugate reduction of the resulting double bond followed by diastereoselective protonation

Asymmetric synthesis of (+)-chloriolide

An asymmetric synthesis of 12-membered ring macrolide, chloriolide has been accomplished by adopting a linear strategy. Lipase-catalyzed enzymatic kinetic resolution (EKR), asymmetric alkynylation using Trost pro-phenol catalyst followed by Yamaguchi macr

Natural product-guided synthesis of a spiroacetal collection reveals modulators of tubulin cytoskeleton integrity

The spiro[5.5]ketal moiety forms the underlying structural skeleton of numerous biologically active natural products. Since simplified but characteristic spiroketals derived from the parent natural products retain biological activity, the spiro[5.5]ketal

MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS

The present invention provides compounds having formula (I), and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1 -R11, t, X, Y, Z, and n are as defined herein.