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17077-45-1

1-(1-Oxo-3-phenyl-2-propenyl)-4-piperidinone, commonly known as MPTP, is a chemical compound that has been extensively studied for its pharmacological and toxicological properties. It is an analog of the synthetic opioid MPPP, which gained notoriety in the 1980s for its neurotoxic effects. While MPTP itself is not a psychoactive drug, it is metabolized in the body into a compound called MPP+, which has been associated with neurotoxicity and the onset of Parkinson's disease-like symptoms. Due to its potential hazards, MPTP is handled with caution in laboratory settings.

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  • 17077-45-1 Structure

  • Basic information

    1. Product Name: 1-(1-Oxo-3-phenyl-2-propenyl)-4-piperidinone
    2. Synonyms: 1-(1-Oxo-3-phenyl-2-propenyl)-4-piperidinone
    3. CAS NO:17077-45-1
    4. Molecular Formula: C14H15NO2
    5. Molecular Weight: 229.27
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 17077-45-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1-(1-Oxo-3-phenyl-2-propenyl)-4-piperidinone(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1-(1-Oxo-3-phenyl-2-propenyl)-4-piperidinone(17077-45-1)
    11. EPA Substance Registry System: 1-(1-Oxo-3-phenyl-2-propenyl)-4-piperidinone(17077-45-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 17077-45-1(Hazardous Substances Data)

17077-45-1 Usage

Uses

Used in Pharmaceutical Research:
1-(1-Oxo-3-phenyl-2-propenyl)-4-piperidinone is used as a research compound for studying the pharmacological effects and mechanisms of action of synthetic opioids. Its conversion to MPP+ in the body provides valuable insights into the neurotoxicity associated with certain drugs and their potential impact on the nervous system.
Used in Parkinson's Disease Research:
In the field of neuroscience, 1-(1-Oxo-3-phenyl-2-propenyl)-4-piperidinone is used as a neurotoxin to induce Parkinson's disease in animal models. This application is crucial for understanding the underlying pathology of the disease and for the development and testing of potential treatments aimed at alleviating or reversing the symptoms of Parkinson's disease.
Used in Toxicology Studies:
1-(1-Oxo-3-phenyl-2-propenyl)-4-piperidinone is utilized as a toxicological agent to investigate the effects of neurotoxic substances on the human body. Its role in inducing Parkinson's disease-like symptoms in animal models allows researchers to study the mechanisms of neurotoxicity and develop strategies to mitigate or prevent such effects.
Used in Drug Safety Assessment:
In the pharmaceutical industry, 1-(1-Oxo-3-phenyl-2-propenyl)-4-piperidinone is used as a reference compound in drug safety assessments. Its known neurotoxic effects help researchers evaluate the safety profiles of new drugs and identify potential risks associated with their use.
Used in Environmental and Occupational Health:
1-(1-Oxo-3-phenyl-2-propenyl)-4-piperidinone is employed in environmental and occupational health studies to assess the potential hazards of exposure to neurotoxic chemicals in various settings. This information is vital for establishing safety guidelines and protocols to protect workers and the general public from the harmful effects of such substances.

Check Digit Verification of cas no

The CAS Registry Mumber 17077-45-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,0,7 and 7 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 17077-45:
(7*1)+(6*7)+(5*0)+(4*7)+(3*7)+(2*4)+(1*5)=111
111 % 10 = 1
So 17077-45-1 is a valid CAS Registry Number.

17077-45-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(3-phenylprop-2-enoyl)piperidin-4-one

1.2 Other means of identification

Product number -
Other names 1-(1-Oxo-3-phenyl-2-propenyl)-4-piperidinone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:17077-45-1 SDS

17077-45-1Downstream Products

17077-45-1Relevant articles and documents

Cytotoxic Amides from Fruits of Kawakawa, Macropiper excelsum

Lei, Jeremy,Burgess, Elaine J.,Richardson, Alistair T. B.,Hawkins, Bill C.,Baird, Sarah K.,Smallfield, Bruce M.,Van Klink, John W.,Perry, Nigel B.

, p. 1163 - 1168 (2015)

Cytotoxic amides have been isolated from the fruits of the endemic New Zealand medicinal plant kawakawa, Macropiper excelsum (Piperaceae). The main amide was piperchabamide A and this is the first report of this rare compound outside the genus Piper. Elev

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