- Lipase-mediated route to diastereo-pure tranexamic acid
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Diastereomerically pure tranexamic acid has been prepared via a diastereomeric separation of a trans-/cis-mixture of 1,4-cyclohexanedimethanol using lipase PS (Pseudomonas sp. Amano).
- Watanabe,Hasegawa,Hiroya,Ogasawara
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- Substituted Imidazopyridines as HDM2 Inhibitors
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The present invention provides substituted imidazopyridines as described herein or a pharmaceutically acceptable salt or solvate thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.
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Paragraph 0709
(2014/07/08)
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- Photoinduced electron transfer of carbazole-acceptor dyads in solution and in a polymer solid
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Photoinduced charge separation (CS) of carbazole-acceptor dyads (Cz-S-A) in solutions and in a polymer solid was examined by the measurement of fluorescence decay. For the discussion of CS from the viewpoint of thermal fluctuations in a solution and in a polymer solid, the separation distance between the Cz donor moiety and acceptor moiety was fixed with a rigid spacer. The photoinduced CS was observed for various solutions with different dielectric constants ranging from 3.06 to 37.5 at room temperature. The rate constant kCS increased with an increase in the free energy gap of -ΔGCS, indicating that CS is in the normal region of the Marcus theory. The temperature dependence of CS in a solution from 183 to 296 K was quantitatively explained by an electron transfer (ET) formula where solvent motions are treated as a classical mode and vibrational motions of the reactant are treated as a quantum mode. On the other hand, the photoinduced CS was also observed for a polymer solid with polar cyano groups over a wide temperature range from 100 to 400 K, although most motions are highly restricted compared with those in a solution. Above the glass transition temperature (T g), CS was explained by the same ET formula as that in a solution with dielectric constants measured at a high frequency. Below Tg, CS was independent of temperature, indicating that CS is caused by nuclear tunneling at low temperatures.
- Ohkita, Hideo,Benten, Hiroaki,Anada, Arihiro,Noguchi, Hitoshi,Kido, Nobuaki,Ito, Shinzaburo,Yamamoto, Masahide
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p. 3977 - 3984
(2007/10/03)
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