170875-37-3

Basic information

• Product Name: 2,4,6-Tribromopyridine 1-oxide
• Synonyms: 2,4,6-Tribromopyridine 1-oxide;2,4,6-tribroMo-1$l^{5}-pyridin-1-one;2,4,6-tribroMopyridine N-oxide;2,4,6-tribromo-1-oxidopyridin-1-ium
• CAS NO: 170875-37-3
• Molecular Formula: C₅H₂Br₃NO
• Molecular Weight: 331.79
• Mol File: 170875-37-3.mol

Chemical Properties

• Boiling Point: 427.373 °C at 760 mmHg
• Flash Point: 212.268 °C
• Appearance: /
• Density: 2.55 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.704
• PKA: -2.36±0.10(Predicted)
• CAS DataBase Reference: 2,4,6-Tribromopyridine 1-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,6-Tribromopyridine 1-oxide(170875-37-3)
• EPA Substance Registry System: 2,4,6-Tribromopyridine 1-oxide(170875-37-3)

Safety Data

• Hazardous Substances Data: 170875-37-3(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2,4,6-Tribromopyridine 1-oxide serves as a valuable building block in organic synthesis, particularly for the preparation of pharmaceuticals and agrochemicals. Its structural features allow for the creation of a wide range of compounds with diverse biological activities.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,4,6-Tribromopyridine 1-oxide is utilized as a key intermediate in the synthesis of various drugs. Its unique structure contributes to the development of new therapeutic agents with improved efficacy and selectivity.
Used in Agrochemical Industry:
Similarly, in the agrochemical industry, 2,4,6-Tribromopyridine 1-oxide is employed as a precursor for the synthesis of pesticides and other crop protection agents, enhancing their effectiveness in controlling pests and diseases.
Used as an Antibacterial Agent:
2,4,6-Tribromopyridine 1-oxide is recognized for its antibacterial properties, making it a candidate for the development of new antimicrobial agents to combat drug-resistant bacteria.
Used as an Antifungal Agent:
Its antifungal properties also position 2,4,6-Tribromopyridine 1-oxide as a potential ingredient in antifungal products, useful in treating fungal infections and controlling mold growth.
Used in Material Science:
In the field of material science, 2,4,6-Tribromopyridine 1-oxide has been investigated for its potential application in designing new functional materials, leveraging its chemical and physical properties to create innovative materials with specialized uses.

InChI:InChI=1/C5H2Br3NO/c6-3-1-4(7)9(10)5(8)2-3/h1-2H

Upstream product

• 98027-81-7 2,6-dibromo-4-nitro-pyridine 1-oxide 
• 506-96-7 Acetyl bromide 

Downstream Products

• 1158786-94-7 4-bromo-N,N'-bis-(2,4-dimethoxy-benzyl)-1-oxy-pyridine-2,6-diamine 
• 920752-30-3 N'-biphenyl-3-yl-N-(2,4-dimethoxy-benzyl)-1-oxy-N''-(2-pyridin-2-yl-ethyl)-pyridine-2,4,6-triamine 
• 920752-29-0 4-bromo-N-(2,4-dimethoxy-benzyl)-1-oxy-N'-(2-pyridin-2-yl-ethyl)-pyridine-2,6-diamine 
• 920752-31-4 N'-biphenyl-3-yl-1-oxy-N-(2-pyridin-2-yl-ethyl)-pyridine-2,4,6-triamine 

Relevant articles and documents

Regioselective synthesis of 2,4,6-triaminopyridines

A regioselective synthesis of 2,4,6-trisubstituted pyridine is described starting from 2,6-dibromo-4-nitropyridine. All three different regioisomers of the 2,4,6-triamino substituted pyridine have been synthesized in four to five steps. The method described is a general route to unsymmetrical 2,4,6-trisubstituted amino pyridines.

Synthesis of [4,6-3H]-2-pyridone and [3H]-RS-91309

We describe herein, a novel synthesis of the previously unreported compound, 4,6-dibromo-2-pyridone (3) and its use in the preparation of [3H]-RS-91309, a potassium channel modulator. This key intermediate, (3), was reduced with carrier free tritium gas to furnish [4,6-3H]-2-pyridone (9) having a specific activity of 50 Ci/mmole. Condensation of (9) with epoxide (10), followed by elaboration of the resulting chromene methyl group of (12) gave [3H]-RS-91309 (14) whose specific activity was also 50 Ci/mmole. This chemistry, as well as the solution of several microscale related stoichiometry problems is discussed.