170962-58-0Relevant articles and documents
Lewis basicity modulation of N-heterocycles: A key for successful cross-metathesis
Lafaye, Kevin,Nicolas, Lionel,Gurinot, Amandine,Reymond, Sbastien,Cossy, Janine
supporting information, p. 4972 - 4975 (2015/01/08)
Cross-metathesis involving N-heteroaromatic olefinic derivatives is disclosed. The introduction of an appropriate substituent on the heteroaromatic ring decreases the Lewis basicity of the nitrogen atom, thus preventing the deactivation of the ruthenium-centered catalyst. The reaction is quite general in terms of both N-heterocycles and olefinic partners.
Antitubercular nitrofuran isoxazolines with improved pharmacokinetic properties
Rakesh,Bruhn, David,Maddox, Marcus,Lee, Robin B.,Yang, Lei,Lee, Richard E.,Madhura, Dora B.,Trivedi, Ashit,Meibohm, Bernd,Scherman, Michael S.,Gilliland, Janet C.,Gruppo, Veronica,McNeil, Michael R.,Lenaerts, Anne J.
, p. 6063 - 6072,10 (2020/08/20)
A series of tetracyclic nitrofuran isoxazoline anti-tuberculosis agents was designed and synthesized to improve the pharmacokinetic properties of an initial lead compound, which had potent anti-tuberculosis activity but suffered from poor solubility, high
UREA INHIBITORS OF MAP KINASES
-
Page/Page column 27, (2010/03/04)
Urea containing compounds that inhibit MAP kinases, pharmaceutical compositions including such compounds and methods for using these compounds to treat inflammatory diseases and cancer are described herein.
Synthesis of Substituted 1,4-Divinylbenzenes by Heck Reactions with Compressed Ethene
Detert, Heiner,Sugiono, Erli
, p. 358 - 362 (2007/10/03)
Substituted 1,4-divinylbenzenes 3a-i were synthesized by twofold Heck coupling from the corresponding 1,4-dibromo- (electron withdrawing substituents) or 1,4-diiododialkoxybenzenes 1a-i and ethene. Oligomerizations could be suppressed by increasing the pressure of ethene to 30 bar, simultaneously improving the yields of the title compounds.
