- LaCl3·7H2O-promoted regioselective ring opening of epoxides using NaNO2 in ether-water system: A facile synthesis of 2-nitroalcohols
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A convenient and efficient synthesis of 2-nitroalcohols has been achieved by regioselective ring opening of epoxides using LaCl3·7H 2O and NaNO2 in ether-H2O system at room temperature. The reaction afforded the corresponding products in good to excellent yields under mild conditions.
- Borah, Jagat C.,Gogoi, Siddhartha,Boruwa, Joshodeep,Barua, Nabin C.
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p. 873 - 878
(2007/10/03)
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- Synthesis of 2-nitroalcohols by regioselective ring opening of epoxides with MgSO4/MeOH/NaNO2 system: A short synthesis of immunosuppressive agent FTY-720
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It has been demonstrated that a variety of epoxides can easily be opened with a system consisting of MgSO4/MeOH/NaNO2 giving the corresponding 2-nitroalcohols in excellent yields. This strategy has been applied to achieve a short synthesis of Immunosuppressive Agent FTY - 720.
- Kalita,Barua,Bezbarua,Bez
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p. 1411 - 1414
(2007/10/03)
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- 2-Amino-2-deoxytetrose derivatives. Preparation from 4,5-dihydroisoxazoles via reductive cleavage
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The 4-alkoxy-3-nitro-4,5-dihydroisoxazoles 2a,b were prepared by condensation of nitromethane and chloroacetaldehyde, protection of the resulting nitroaldol 1c, and subsequent nitrosative cyclization. Multistep replacement of the nitrogroup of 2a,b by a 2
- Wade,D'Ambrosio,Price
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p. 6302 - 6308
(2007/10/03)
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