171560-22-8Relevant articles and documents
The total synthesis of pamamycin-607. Part 2: Synthesis of the C6-C18 domain
Fraser, Benjamin H.,Mulder, Roger J.,Perlmutter, Patrick
, p. 2857 - 2867 (2007/10/03)
Synthesis of the C6-C18 domain of pamamycin-607 was achieved in ten steps and 7% overall yield from commercially available d-norvaline. The key asymmetric transformations included a Paterson anti aldol addition, an anti selective reduction of the resultan
Chiral aminal templates: Diastereoselective addition to hydrazones; an asymmetric synthesis of α-amino aldehydes
Alexakis,Lensen,Tranchier,Mangeney,Feneau-Dupont,Declercq
, p. 1038 - 1050 (2007/10/02)
The monohydrazone of glyoxal may be derivatized into a chiral aminal with diamine 7. The resulting chiral reagent 13 reacts with complete diastereocontrol with organolithium reagents in THF. This sterically controlled reaction may be altered to chelation