57521-85-4

Usage

Uses

Used in Pharmaceutical Industry:
BOC-D-NVA-OH is used as a chemical reagent for the preparation of benzothiophene inhibitors of MK2, a protein kinase involved in various cellular processes, including inflammation and cancer. BOC-D-NVA-OH plays a vital role in the development of potential therapeutic agents targeting MK2, which could have significant implications in the treatment of various diseases.
Used in Cancer Research:
BOC-D-NVA-OH has been utilized in the synthesis of pyrrolidine diketopiperazines, a class of compounds that exhibit inhibitory effects on melanoma, a type of skin cancer. By incorporating this reagent into the synthesis process, researchers can develop novel inhibitors with potential applications in cancer treatment and prevention.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 138611-25-3 (2R,3R)-3-(α-phenylbenzylamino)-1,2-hexanediol 
• 2013-12-9 D-norvaline 
• 116611-52-0 [(S)-2-Benzenesulfonyl-1-(tetrahydro-pyran-2-yloxymethyl)-butyl]-carbamic acid tert-butyl ester 
• 116611-61-1 ((S)-2-Benzenesulfonyl-1-hydroxymethyl-butyl)-carbamic acid tert-butyl ester 
• 116611-50-8 ((S)-2-Benzenesulfonyl-1-hydroxymethyl-ethyl)-carbamic acid tert-butyl ester 
• 116611-47-3 Toluene-4-sulfonic acid (S)-2-tert-butoxycarbonylamino-3-(tetrahydro-pyran-2-yloxy)-propyl ester 
• 116611-48-4 [(S)-2-Phenylsulfanyl-1-(tetrahydro-pyran-2-yloxymethyl)-ethyl]-carbamic acid tert-butyl ester 
• 116611-63-3 methyl N-(tert-butoxycarbonyl)-O-(tetrahydro-2H-pyran-2-yl)-L-serinate 
• 116611-46-2 tert-butyl [(2R)-1-hydroxy-3-(tetrahydro-2H-pyran-2-yloxy)propan-2-yl]carbamate 
• 116696-85-6 (2S)-2-t-butoxycarbonylamino-3-phenylsulfonyl-1-(2-tetrahydropyranyloxy)propane 
• 116611-49-5 ((S)-1-Hydroxymethyl-2-phenylsulfanyl-ethyl)-carbamic acid tert-butyl ester 
• 2766-43-0 N-tert-butyloxycarbonyl-L-serine methyl ester 
• 138665-25-5 (2R,3R)-3-amino-1,2-hexanediol 

Downstream Products

• 177659-59-5 (S)-1-((R)-2-tert-Butoxycarbonylamino-pentanoyl)-pyrrolidine-2-carboxylic acid benzyl ester 
• 928025-41-6 (R)-1-benzyl-3-propylpiperazine 

Relevant academic research and scientific papers

NOVEL COMPOUNDS

The present invention relates to compounds, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, for example as modulators of alpha 1 antitrypsin and treating diseases associated with alpha antitrypsin, particularly liver diseases.

NOVEL COMPOUNDS

Disclosed are novel retinoid-related orphan receptor gamma (RORγ) modulators and their use in the treatment of diseases mediated by RORγ.

Synthesis of optically active β,γ-alkynylglycine derivatives

Full results on the first synthesis of optically active β,γ-alkynylglycine derivatives from naturally occurring L-serine are described. The methodology uses L-serinal as a key intermediate and allows great versatility in the introduction of N-protective groups and of alkyne substitution. The N-Boc protected β,γ-alkynylglycine derivatives described have ee greater than 90%.

Benzo-fused lactams that promote the release of growth hormone

There are disclosed certain novel compounds identified as benzo-fused lactams which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to increase the stature of those afflicted with a lack of a normal secretion of natural growth hormone. Growth promoting compositions containing such benzo-fused lactams as the active ingredient thereof are also disclosed.

A short enantioselective synthesis of N-Boc-α-amino acids from epoxy alcohols

A new and efficient enantioselective synthesis of Boc-α-amino acids has been developed. Starting from an enantiomerically enriched epoxy alcohol the sequence involves a regioselective nucleophilic epoxide opening by diphenylmethylamine (benzhydrilamine), hydrogenolysis/ protection of the amino group, and oxidation of the diol moiety.

A NOVEL APPROACH TO THE SYNTHESIS OF OPTICALLY PURE NON PROTEIN α-AMINO ACIDS IN BOTH L AND D CONFIGURATIONS FROM L-SERINE

Efficient syntheses of (2R)-2-Boc-amino-3-phenylsulfonyl-1-propanol 3 and its enantiomer 9 from L-serine are described.The potential of these compounds in a novel general method for the synthesis of optically pure non protein α-amino acids in both the L and D configurations is exemplified by the preparation of N-Boc-L-and D-homophenylalanine,-norvaline and -norleucine.