- Trifluoromethylation of haloarenes with a new trifluoro-methylating reagent Cu(O2CCF2SO2F)2
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A new trifluoromethylating reagent Cu(O2CCF2SO2F)2, which easily decomposes to generate active CuCF3 species in DMF at room temperature, has been conveniently prepared from inexpensive starting materials on a large scale. This new reagent can be applied to efficiently trifluoromethylate a variety of haloarenes under mild conditions, providing good-to-excellent yields of the desired products.
- Zhao, Gang,Wu, Hao,Xiao, Zhiwei,Chen, Qing-Yun,Liu, Chao
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p. 50250 - 50254
(2016/06/15)
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- Free radical fluoroalkylation of terminal alkenes and alkynes with iododifluoromethanesulfonamides
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Free radical fluoroalkylation of terminal alkenes and alkynes with iododifluoromethanesulfonamides has been successfully achieved. It was found that both the catalytic amount of sodium dithionite (Na2S 2O4) and the stoichiometric amount of triethylborane (Et3B)/air can efficiently initiate the current free-radical atom transfer reaction.
- Zhu, Jieming,Wang, Fei,Hu, Jinbo
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scheme or table
p. 95 - 102
(2011/12/15)
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- Process for the production of trialkylsilyl(fluorosulfonyl)difluoroacetate
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A process for the production of trialkylsilyl (fluorosulfonyl)difluoroacetate by contacting (fluorosulfonyl)difluoroacetyl fluoride with siloxane. The amount of (fluorosulfonyl)difluoroacetic acid by-product in trialkylsilyl(fluorosulfonyl)difluoroacetate is reduced by contacting said mixture with trialkylsilyl halide.
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Page/Page column 3-4
(2008/06/13)
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- Zn(ODf)2: Preparation and application in asymmetric alkynylation of aldehydes
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A new Lewis acid, Zn(ODf)2, was first prepared from commercially available 3,3,4,4-tetrafluoro[1,2]oxathietane 2,2-dioxide in four steps with 56% yields and also was applied to catalyze highly enantioselective alkynylation of aldehydes in the presence of ligand (1S,2S)-3-(tert-butyldimethylsilyloxyl)-2-N,N-dimethylamino-1-(p- nitrophenyl)-propane-1-ol or ligand (-)-N-methylephedrine to afford the corresponding propargylic alcohols in high yields with up to 99% ee.
- Chen, Zili,Xiong, Wennan,Jiang, Biao
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p. 2098 - 2099
(2007/10/03)
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