1717-59-5

Usage

Uses

Used in Organic Synthesis:
2-(Fluorosulfonyl)difluoroacetic acid is used as an important reagent for the synthesis of difluorocarbenes and difluorocyclopropanes. It serves as a difluorocarbene source for difluoromethylation of phenolic hydroxyl groups, which is a crucial step in the creation of various organic compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-(Fluorosulfonyl)difluoroacetic acid is used as an important raw material and intermediate in the synthesis of various drugs. Its unique reactivity allows for the creation of complex molecular structures that can be used as active pharmaceutical ingredients.
Used in Agrochemicals:
2-(Fluorosulfonyl)difluoroacetic acid is also utilized in the agrochemical industry as a key intermediate for the synthesis of various pesticides and other agricultural chemicals. Its ability to form difluorocarbenes and difluorocyclopropanes makes it a valuable component in the development of new and effective agrochemical products.
Used in Dye Industry:
In the dye industry, 2-(Fluorosulfonyl)difluoroacetic acid is used as a crucial intermediate for the synthesis of various dyes and pigments. Its unique properties enable the creation of dyes with specific color characteristics and improved performance properties.

InChI:InChI=1/C2HF3O4S/c3-2(4,1(6)7)10(5,8)9/h(H,6,7)

Upstream product

• 677-67-8 fluorosulfonyldifluoroacetyl fluoride 
• 107-46-0 Hexamethyldisiloxane 
• 697-18-7 tetrafluoroethane-β-sultone 
• 7732-18-5 water 
• 18225-70-2 chlorosulfonyldifluoroacetic acid 
• 7664-39-3 hydrogen fluoride 

Downstream Products

• 75-46-7 trifluoromethan 
• 359-15-9 difluoromethyl methyl ether 
• 1583-83-1 4-methyl-α,α-difluoroanisole 
• 3856-58-4 difluoromethoxypentafluorobenzene 
• 1885-09-2 difluoromethyl benzoate 
• 101817-80-5 Difluoro-methanesulfonic acid difluoromethyl ester 
• 105198-13-8 difluoromethyl acetate 
• 120608-95-9 Diethyl-dithiocarbamic acid difluoromethyl ester 
• 1535-65-5 difluoromethyl phenyl sulfone 
• 14277-20-4 difluoromethyl 4-methylbenzenesulfonate 
• 120608-91-5 difluoromethyl 3-nitrobenzenesulfonate 
• 120608-81-3 Heptanoic acid difluoromethyl ester 
• 1885-46-7 trifluoromethanesulfonic acid difluoromethyl ether 
• 120608-85-7 4-Methyl-benzoic acid difluoromethyl ester 

Relevant academic research and scientific papers

Trifluoromethylation of haloarenes with a new trifluoro-methylating reagent Cu(O2CCF2SO2F)2

A new trifluoromethylating reagent Cu(O2CCF2SO2F)2, which easily decomposes to generate active CuCF3 species in DMF at room temperature, has been conveniently prepared from inexpensive starting materials on a large scale. This new reagent can be applied to efficiently trifluoromethylate a variety of haloarenes under mild conditions, providing good-to-excellent yields of the desired products.

Free radical fluoroalkylation of terminal alkenes and alkynes with iododifluoromethanesulfonamides

Free radical fluoroalkylation of terminal alkenes and alkynes with iododifluoromethanesulfonamides has been successfully achieved. It was found that both the catalytic amount of sodium dithionite (Na2S 2O4) and the stoichiometric amount of triethylborane (Et3B)/air can efficiently initiate the current free-radical atom transfer reaction.

Process for the production of trialkylsilyl(fluorosulfonyl)difluoroacetate

A process for the production of trialkylsilyl (fluorosulfonyl)difluoroacetate by contacting (fluorosulfonyl)difluoroacetyl fluoride with siloxane. The amount of (fluorosulfonyl)difluoroacetic acid by-product in trialkylsilyl(fluorosulfonyl)difluoroacetate is reduced by contacting said mixture with trialkylsilyl halide.

Zn(ODf)2: Preparation and application in asymmetric alkynylation of aldehydes

A new Lewis acid, Zn(ODf)2, was first prepared from commercially available 3,3,4,4-tetrafluoro[1,2]oxathietane 2,2-dioxide in four steps with 56% yields and also was applied to catalyze highly enantioselective alkynylation of aldehydes in the presence of ligand (1S,2S)-3-(tert-butyldimethylsilyloxyl)-2-N,N-dimethylamino-1-(p- nitrophenyl)-propane-1-ol or ligand (-)-N-methylephedrine to afford the corresponding propargylic alcohols in high yields with up to 99% ee.